Initial attempts to develop an effective vaccine for controlling both animal and human chlamydial infections began with the use of inactivated or live whole organism preparations in the 1950s, e.g. for C. abortus in sheep. In general, such preparations offered a reasonable level of protection, ...
All annotated genomes (S26/3, LLG, AB7, 1B) [Seth-Smith, H.M.B. et al: Genomic evidence that the live Chlamydia abortus vaccine strain 1B is not attenuated and has the potential to cause disease, in preparation] were curated for the presence of pseudogenes. Pseudogenes were defined as...
The present invention describes an efficient vaccine against a Chlamydia trachomatis (Ct). The vaccine is based on recombinant fusion molecules that are capable of generating
Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion. Vaccine. 2010;28: 5657–63. Development of a molecular DIVA to distinguish animals infected with wild-type C. abortus strains from those infected with the live attenuated vaccine strain and ...
abortus (1B strain) as a vaccine was investigated. The result was the production of a commercial vaccine (Enzovax*), which is not available in North America. When injected in ewes or does before breeding, it did not interfere with the subsequent gestation, it protected against abortion, and...
There have been a number of attempts in the past 70-plus years to create an effective vaccine to protect livestock from Chlamydia infections but none have been very successful. Currently, only two chlamydial vaccines are available commercially and they target C. felis in cats and C. abortus in...
China ABSTRACT Chlamydia infection is an important cause of public health diseases, and no effective vaccine is currently available. Owing to its unique intracellular lifestyle, Chlamydia requires a variety of nutrients and substrates from host cells, particularly sphingomyelin, cholesterol, iron, ...
The UMA vaccine technology would be expected to cover all chlamydial infections, including those caused by Chlamydia psittaci, which often results in pneumonia and endocarditis in humans, and Chlamydia pneumoniae, which is responsible for some pneumonia, bronchitis, pharyngitis, laryngitis, and sinusiti...
abortus infectivity. From this it was identified that infection of PG-1-pretreated cells resulted in an eight-fold increase in the number of inclusions and that PG-1 treatment after chlamydial infection had no increase in infectivity. Additional experiments demonstrated that PG-1 pretreatment ...
Immunology of Chlamydia infection: Implications for a Chlamydia trachomatis vaccine. Nat. Rev. Immunol 2005, 5, 149–161. [Google Scholar] [CrossRef] [PubMed] Bavoil, P.; Ohlin, A.; Schachter, J. Role of disulfide bonding in outer membrane structure and permeability in Chlamydia ...