Nephropathic cystinosis is an inherited autosomal recessive lysosomal storage disorder characterized by the pathological accumulation and crystallization of cystine inside different cell types. WBC cystine determination forms the basis for the diagnosis
Chitoporin (VhChiP) is a sugar-specific channel responsible for the transport of chitooligosaccharides through the outer membrane of the marine bacterium Vibrio harveyi. Single channel reconstitution into black lipid membrane allowed single chitosugar binding events in the channel to be resolved. Vh...
VhChiP is a sugar-specific porin present in the outer membrane of the marine bacterium Vibrio harveyi. VhChiP is responsible for the uptake of chitin oligosaccharides, with particular selectivity for chitohexaose. In this study, we employed electrophysiological and biochemical approaches to demonstrate...
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Single channel reconstitution into black lipid membrane allowed single chitosugar binding events in the channel to be resolved. VhChiP has an exceptionally high substrate affinity, with a binding constant of K = 5.0 脳 106 M -1 for its best substrate (chitohexaose). The on-rates of chito...
Chitin is an important structural component of numerous fungal pathogens and parasitic nematodes. The human macrophage chitotriosidase (HCHT) is a chitinase that hydrolyses glycosidic bonds between the N-acetyl-D-glucosamine units of this biopolymer. HCH
biochemical reagents; The reference substance for the analysis and quality control of oligosaccharides; The preparation of oligosaccharide chip; The interaction between oligosaccharides and protein; oligosaccharide drug structure activity relationship and mechanism of sugar chemistry and sugar biology research ...
Hatanaka T Nitoda T MESH Carbohydrate Conformation Dose-Response Relationship, Drug Enzyme Inhibitors Molecular Probes Structure-Activity Relationship Substrate Specificity Sugar Alcohols beta-N-Acetylhexosaminidases Try the Free App: Prime PubMed is providedfr...
The structure of 1 was determined by spectral and constitutive sugar analyses of the corresponding alditol derivatives to be an equilibrated mixture of α-d-N,N,N-triMeGlcNH2-(1,4)-β-d-GlcNAc-(1,4)-β-d-GlcNAc-(1,4)-d-GlcNAc and its C-2 epimer of the reducing end residue. TMG-...
burgdorferi genome identified a number of genes that are homologous to those known to play a role in DNA replication/repair, recombination, intracellular transport and energy metabolism in other bacterial species (Casjens et al., 2000; Fraser et al., 1997). Genome sequence analysis also showed ...