Chitin synthesis in human pathogenic fungiS. cerevisiae A. nidulans C. albicans A. fumigatusC. A. MUNRON. A. R. GOW
The relevance of fungal chitin synthesis in human disease is also evident in emerging research defining the role of this fungal signature molecule in immune recognition mechanisms. References and recommended reading Papers of particular interest, published within the annual period of review, have been ...
In fungi, after their synthesis, the Chs are packaged into microvesicles with a diameter of approximately 60 nm, called chitosomes (Leal-Morales et al., 1988). These chitosomes bring the Chs to the hyphal tip of the cell membrane. Recently, it was demonstrated that all the seven Chs from...
Human mycoses have become a threat to health world-wide. Unfortunately there are only a limited number of antimycotic drugs in use. Promising targets for drugs specific against fungi are those affecting chitin synthesis. Chitin is absent in vertebrates, and is essential for fungal wall integrity. ...
The antifungal protein AFP from Aspergillus giganteus is highly effective in restricting the growth of major human- and plant-pathogenic filamentous fungi. However, a fundamental prerequisite for the use of AFP as an antifungal drug is a complete understanding of its mode of action. In this study...
This latter is a highly potent inhibitor of chitin synthesis and affects plasma membrane integrity in many human and plant pathogenic fungi. A transcriptomic... M Vera,J Sascha - 《Microorganisms》 被引量: 6发表: 2018年 From sporadic single genes to a broader transcriptomic approach: Insights in...
The ability to hydrolyze chitin may be a useful characteristic in differentiating serratiae from other Enterobacteriaceae. However, many more strains will have to be tested for chitinase synthesis before the usefulness of the test can be determined. 展开 ...
sylvestris roots were challenged with H. annosum, but not by the other fungi. These results suggest that β-N-acetylglucosaminidase might be an important early response to chitinous pathogens. 展开 关键词: Eucalyptus pilularis Pinus sylvestris (Scots pine) chitinolytic activities mycorrhiza pathogen ...
The synthesis of chitin is mediated by several enzymes named chitin synthases. Chitin provides structural integrity and when its synthesis is disrupted, the cell wall becomes osmotically unstable. Because chitin is absent in human cells, it is considered an excellent target for antifungal agents. ...
Plasmodiophorids chitin synthases belong to two families, which were present before the split of the eukaryotic Stramenopiles/Alveolates/Rhizaria/Plantae and Metazoa/Fungi/Amoebozoa megagroups, suggesting chitin synthesis to be an ancient feature of eukaryotes. This exemplifies the importance of genomic...