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Chiralpak^(■)IG columnMolecular dockingBinding energyEnantioseparation of threeβ-blockers,i.e.,atenolol,metoprolol and propranolol,was studied on amylose tris(3-chloro-5-methylphenylcarbamate)immobilized chiral stationary phase using supercritical fluid chromatography(SFC).The effect of organic modifiers(...
Column: Chiralpak® IG; temperature: 40 °C; back pressure: 100 bars; detection wavelength: 220 nm; flow rate: 4 mL/min. α1, α2, and α3: separation factors between enantiomers of metoprolol (α1), propranolol (α2), and atenolol (α3). A: atenolol; M: metoprolol; P: ...