in the northeast part of the state on Lake Michigan. Located at the mouth of theChicago River,the first link in the Illinois Waterway, it developed into a major port in the 1800s and became the commercial center of the Midwest. Chicago was nearly destroyed by a disastrous fire in 1871. ...
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Lookup box Close University of Chicago (redirected from The University of Chicago)Also found in: Thesaurus. ThesaurusAntonymsRelated WordsSynonymsLegend: Switch to new thesaurus Noun 1. University of Chicago - a university in Chicago, Illinois Chicago, Windy City - largest city in Illinois; a...