chemotherapy and the 159 who did not [hazard ratio ( HR ) 0.94, 95% CI 0.66–1.32, P = 0.700) and no significant difference in colon‐cancer‐specific death ( HR 0.73, 95% CI 0.50–1.04, P = 0.084; HR 0.88, 95%
After completing surgery and chemotherapy, nearly one-third of people with high-risk colon cancer may eventually experience recurrence of their disease. Tom Gavin, EverydayHealth.com, 3 June 2025 In a study published in The New England Journal of Medicine in 2022, researchers in Australia used ...
The standard adjuvant therapy for resected stage III colon cancer has been intravenous 5-fluorouracil. However, newer chemotherapy agents, such as capecitabine, oxaliplatin and irinotecan, have been investigated in clinical trials since the publication of the original guidelines. The Gastrointestinal Cancer...
In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3–8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L),...
Ciccolini J, Peillard L, Evrard A, Cuq P, Aubert C, Pelegrin A, Formento P, Milano G, Catalin J (2000) Enhanced antitumor activity of 5-fluorouracil in combination with 2′-deoxyinosine in human colorectal cell lines and human colon tumor xenografts. Clin Cancer Res 6: 1529–1535 CAS ...
Introduction The results of adjuvant chemotherapy trials in stage II/III colon cancer are often extrapolated to real-world patients. This study was conducted to determine the proportion of real-world patients with stage II/ III colon cancer who would be eligible for adjuvant chemotherapy trials and...
We therefore conducted a prospective cohort study named the B-CAST study (Biomarker-cohort study of adjuvant chemotherapy for stage III colon cancer), to identify the patients who benefit from adjuvant chemotherapy with each 5-FU derivative, through evaluating the relationships between tumor biomarker ...
chemotherapy game-changer for stage 4 cancer for years, patients and doctors have been asking, "why does chemotherapy only work for some patients and not others?" for example, a patient may try a different chemo regimen over and over, may "respond" to chemotherapy and have 30% tumor ...
BMC Cancer (2020) 20:790 https://doi.org/10.1186/s12885-020-07252-y STUDY PROTOCOL Open Access Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study S. J. Schraa1†, K. L. van Rooijen1†, D....
There isn’t one “best” type of chemotherapy drug. Which drug will work best for you depends on many different things. You and your doctor will choose which drug(s) to use based on your: Cancer type and stage Previous cancer treatments ...