The article presents information on studies about the link between chemotherapy and brain damage. The author states that recent studies have shown that drugs used for treating cancer can damage the brain. The author added that chemother...
IN)(Brief article) Chemotherapy May Cause Brain Damage.(JUST IN)(Brief article)Chemotherapy May Cause Brain Damage.(JUST IN)(Brief article)McBride, Deborah
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event associated with several antineoplastic drugs; however, the precise risks and time course of reactions of particular drugs are not clearly understood. The aim of this study was to evaluate the relationship between anticancer agen...
Because infiltrative tumors interdigitate with normal brain cells and are not highly sensitive to irradiation, one cannot expect radiotherapy to be curative without serious damage to normal brain cells. The hope for a cure, then, rests with chemotherapy. Those who administer chemotherapy to patients...
The lipophilic drugs have the advantages of greater penetrability of and preferential partitioning in and cellular structures. Potentially, combinations of differently acting CCNS agents should maximize DNA damage and prevent DNA repair. Infusions of drugs for 3 to 4 days, following an interval of 6...
It’s called "chemo brain" or "chemo fog." To keep yourself on track, try a few of these steps: Stick to a routine. Take notes and use a planner. Cut down on distractions at work and elsewhere. Use a pill box to keep track of your medications. Mouth and Throat Sores Painful ...
changes induced by chemotherapy might paradoxically promote survival and growth of disseminated cancer cells at distant organs5,6,7,8, thus abating the beneficial effects of chemotherapy. These pro-tumorigenic adverse effects are largely due to the induction of tissue damage and tumor-promoting ...
• Damage to neuronal cell bodies in the dorsal root ganglion • Axonal toxicity (demyelination, impaired transport) • Axonal membrane ion channel dysfunction (Na+ channel) • Mitochondrial damage and inflammation • Vascular changes • Protein C kinase epsilon isoform(PKCε) • Cytokine...
The numerous chemotherapy treatment protocols for pediatric brain tumors reflect the extreme heterogeneity of these neoplasms. In the setting of average-risk medulloblastoma and germinoma, which have high cure rates with radiation treatment alone, chemotherapy is used to reduce radiation doses, yet mainta...
Two years ago, Noble and his team showed that three common chemotherapy drugs used to treat a wide range of cancers were more toxic to healthy brain cells than the cancer cells they were intended to treat. While these experiments were among the first to establish a biological basis for the ...