probiotic lactobacilli have the potential to be used as alternatives for lessening chemotherapy-induced immunosuppression in cancer patients” (Salva 2014). A rigorous literature review found that probiotics re
Chemotherapy, which is frequently one of the first-line treatments, frequently suffers from low selectivity to cancer cells, leading to the appearance of important side effects. Thus, it becomes imperative to develop a new generation of targeted alternatives that spare the healthy tissues by ...
Small molecule ligands (with molecular weight < 0.5 kDa) [21] are fast-becoming attractive alternatives to antibodies for cancer-targeted drug conjugates owing to their non-immunogenicity tunable synthesis, and better cell penetration due to their low molecular weights [118], [174]. Folate and...
Chemotherapy can cure some types of cancer. In some cases, it is used to slow the growth of cancer cells or to keep the cancer from spreading to other parts of the body. Chemotherapy may be given before surgery or radiation therapy to shrink the tumor (neoadjuvant therapy). When a cancer...
Colorectal cancer (CRC) therapy efficiency can be influenced by the microbiota in the gastrointestinal tract. Compared with traditional intervention, prebiotics delivery into the gut is a more controllable method for gut microbiota modulatory therapy. Capecitabine (Cap), the first-line chemotherapeutic age...
Yellow: CEN/KT genes that are differentially expressed in nine cancer types relative to their corresponding normal tissues as shown in Fig. 1b. Red: CEN/KT genes with significant prognostic values for breast cancer patients using BC-GenExMiner, and (green) those with significant prognostic values...
Neoadjuvant chemotherapy (NAC) is a well-established treatment modality for locally advanced breast cancer (BC). However, it can also result in severe toxicities while controlling tumors. Therefore, reliable predictive biomarkers are urgently needed to o
Radiotherapy, chemotherapy, and surgery are the only effective techniques to combat advanced stages of cancer approximately till the age of 50 years [18] Traditional herbs and their structural analogues are the alternatives and biocompatible approaches to combat cancer cell proliferation and metastasis, ...
Despite substantial advances in the treatment of various cancers, many patients still receive anti-cancer therapies that hardly eradicate tumor cells but inflict considerable side effects. To provide the best treatment regimen for an individual patient, a major goal in molecular oncology is to identify...
the most typical of which is the accelerated blood clearance phenomenon.25 In previous studies, we26 and other researchers27 have demonstrated that the zwitterionic polymers were suitable alternatives of PEG, showing benefits due to their good biocompatibility, antifouling properties, pH responses, and ...