Given their role in regulating the migration and cell-cell interactions of immune cells, chemokines are intimately involved with both anti-tumor and pro-tumor immune responses as well as the response and resistance to cancer therapies. Chemokines participate in the generation of anti-tumor immune res...
We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as ...
Chemokines and the immune response to cancer Immunity, 54 (2021), pp. 859-874, 10.1016/j.immuni.2021.01.012 View PDFView articleView in ScopusGoogle Scholar [23] W. Kastenmüller, M. Brandes, Z. Wang, J. Herz, J.G. Egen, R.N. Germain Peripheral prepositioning and local CXCL9 chemok...
We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as ...
In this Review, we focus on the main chemokines that are found in the human tumour microenvironment; we elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology, and we consider how they affect cancer immunity ...
Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response. Cancer Sci 2007; 98:1652-8... K Koizumi,S Hojo,T Akashi,... - 《Cancer Science》 被引量: 0发表: 2007年 Involvement of chemokine receptors in breast cancer metastasis. Reports that the chemok...
These chemokines mediate leukocyte homing to sites of wounding or inflammation, thus instigating the immune response. With respect to cancer progression, CXC chemokines have been found to play critical roles in tumor angiogenesis, tumor growth, tumor cell invasion, and metastasis. Characteristics CXC ...
Interaction between the immune system and cancer allows for the use of biological response modifiers, e.g. OK-432, in cancer therapy. OK-432, penicillin-killed Streptococcus pyogenes, is used in treating carcinomas, but also lymphangioma... C Olsnes,J Olofsson,HJ Aarstad - 《Scandinavian Jour...
Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chem
Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have demonstrated stunning clinical efficacy in many cancer types. However, most patients do not respond to immunotherapies or relapse after an initial response, stressing the need for improved strategies. Chemokines, as med...