Triple negative breast cancer (TNBC) accounts for 15–20% of breast cancer cases in the United States. Systemic neoadjuvant chemotherapy (NACT), with or without immunotherapy, is the current standard of care for patients with early-stage TNBC. However, up to 70% of TNBC patients have significa...
Anew studyof 453 stage II colon cancer patients found that the patients who were treated with chemotherapy had worse quality of life (no surprise there), and were on average nearly three times more likely to have a cancer recurrence, and two times more likely to die within two years of the...
Doxorubicin (DOX) is one of the mostly used chemotherapeutic medications for breast cancer. While DOX treatment initially causes clini- cal responses, its longstanding success may be halted due to the emergence of drug toxicities and resistance55. Currently, combining the natural products with ...
Juicing is the first thing a patient should do when they receive a cancer diagnosis. It allows for maximum absorption of a vast amount of nutrients. Following chemotherapy, juicing is an excellent way to supply nutrients to the body for absorption and to begin the healing process. The benefits...
Gligorich K, Vaden R, Shelton D, Wang G, Matsen C, Looper R, Sigman M, Welm B: Development of a screen to identify selective small molecules active against patient- derived metastatic and chemoresistant breast cancer cells. Breast Cancer Res 2013, 15:R58....
Further, inhibition of BET proteins also led to attenuation of RAD51 and BRCA1 proteins in breast, ovarian, and prostate cancer models [2]. PI3K inhibition is also sufficient to reduce BRCA1 and BRCA2 expression, hampering HR repair in triple-negative breast cancer [40]. Other reported ...
Just like real chemo was a necessary evil to rid my mother of cancer, “financial chemo” (rate hikes and QT) is a necessary evil to rid the economy of inflation. But the economy hasn’t started treatments yet, and just like my family was taken aback by how hard those chemo treatments...
Although polyploid giant cancer cells (PGCCs) are known as a key source of failure of current therapies, sufficient drugs to target these cells are not yet introduced. Considering the similarities of polyploid cells in regeneration and cancer, we hypothe
This study reports on an intelligent composite hydrogel with both pH-dependent drug release in a cancer environment and heat generation based on NIR laser exposure, for the combined application of photothermal therapy (PTT) and multidrug chemotherapy. Fo
Signaling through CXCR4 mediates actin polymerization and pseudopodia formation in breast cancer cells, and induces chemotactic and invasive responses. Additionally, the organs representing the main sites of breast cancer metastasis (such as lymph nodes, bone marrow, and lungs) are the most abundant ...