Over the last decade, the use of immune checkpoint inhibitors (ICI) has dramatically changed the treatment paradigm and outcome of patients with nonsmall cell lung cancer (NSCLC) across all stages of the disease. In this review, we provide a concise history of the use of ICIs in the ...
ICI-antiangio-chemo方案在PFS和DCR方面相比化疗或ICI单药治疗有显著改善。此外,研究者指出了生物标志物如PD-L1表达水平、EGFR突变类型和Thr790Met突变状态在预测治疗反应中的重要性,并强调个体化治疗策略的必要性。 尽管ICI-antiangio-chemo...
chemoimmunotherapy regimen is theoretically more effective than a non-bevacizumab-containing regimen via two mechanisms: a superior outcome of bevacizumab-containing chemothrerapy than the standard platinum doublet regimen, and the synergistic effect of bevacizumab with an immune checkpoint inhibitor (ICI)...
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—: Contributi morfologici allo studio dei recettori aortico-arteriosi dei riflessi cardiopressoregolatori. Arch. ital. Anat. Embriol. 38, 387–427 (1937b). Google Scholar —: Aspetti istologici dell'innervazione e significato embriologico della sede della zone arteriose pressorecettrici...
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ICI: Immune-checkpoint inhibitor; IFN: Interferon; IgG: Immunoglobulin G; IL: Interleukin; MHC: Major histocompatibility complex; mOS: Median overall survival; NK: Natural killer; NKG2D: Natural killer group 2 member D; NKT: Natural killer T; NSCLC: Non-small cell lung cancer; ORR: Overall ...
Current pre-treatment methods to determine which patients will benefit from ICI therapy—and which will experience harmful side effects—don't always work. CX3CR1 is the next best thing: an "early-on" treatment biomarker that is noninvasive. It can be measured when patients attend their first...
ICIs targeting the PD-1/PD-L1 pathway augment endogenous antitumor responses, and several ICI trials are conducted to treat the R/M HNSCC and find promising outcomes. Radiotherapy may improve responses to immune therapy by shaping the tumor microenvironment and impacting the affluence and composition...
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