This indicates the long-term persistence of drug-resistant cells. These results were further supported by our analysis of two large public AML cohorts, which showed that the presence of a high percentage of CD69+ HSC-like cells (CD69+-high) was associated with significantly higher rates of ...
In addition, we were particularly interested in investigating the regulatory network to provide mechanistic information related to drug resistance. Upstream regulator analysis identified MTOR and STAT3 as two major suppressed hubs, which were associated with decreased expression of cell cycle regulators (e....
Overexpression of NGAL persuades EMT via activation of snail, twist, N-cadherin, fibronectin, MMP-9, and NF-κB; it then upregulates the genes associated with stemness, adhesion, motility, and drug efflux [14–16]. Likewise, silencing of NGAL reduces migration and invasion via the ...