The chemical reactions of metabolism are organized into metabolic pathways , in which one chemical is transformed through a series of steps into another chemical, by a sequence of enzymes . 代谢中的化学反应可以归纳为代謝途徑 ,通过一系列酶 的作用将一种化学物质转化为另一种化学物质。 ParaCrawl ...
These chemical reactions take place in a series of well regulated stages, and it is convenient to group the stages together to give a metabolic pathway for a particular compound.doi:10.1007/978-1-349-16250-5_9J. G. DawberA. T. Moore...
Chemical biology is the study of the chemicals and chemical reactions involved in biological processes, incorporating the disciplines of bioorganic chemistry, biochemistry, cell biology and pharmacology. Chemicals – including natural small molecules, such as lipids, carbohydrates and metals, or non-natural...
Comparative analyses of enzymatic reactions provide important information on both evolution and potential pharmacological targets. Previously, we focused on the structural formulae of compounds, and proposed a method to calculate enzymatic similarities based on these formulae. However, with the proposed met...
SAMPLE is a general protein engineering platform that can be broadly applied to diverse protein engineering targets and functions. Although we only demonstrated thermostability engineering, the same general approach could engineer enzyme activity, specificity and even new-to-nature chemical reactions. Like...
Biocatalysts can accelerate the catalysis of a chemical reaction that is difficult to synthesize with typical chemical methods. The global enzyme market size is predicted to expand at a CAGR of 6.5% from 2021 to 2028. Enzymatic reactions are highly chemo, regio, and stereoselective and produce var...
Prather was intrigued by the possibility of performing not just individual steps but the entire chemical synthesis within cells, using chains of reactions called metabolic pathways. That work inspired what would become some of her most acclaimed research at MIT, where she joined the faculty in 200...
select article Ion-imprinted magnetic adsorbents for the selective capture of Cu(II) and their cascade application as heterogeneous recyclable catalysts for Ullmann and Glaser coupling reactions Research articleAbstract only Ion-imprinted magnetic adsorbents for the selective capture of Cu(II) and their ...
Acetyl-CoA assimilation pathways are usually associated with the loss of carbon in the form of CO2. Here, the authors report a new metabolic pathway enabled by an engineered B12-dependent acyl-CoA mutase, in which CO2is fixed during acetyl-CoA assimilation. ...
Oscillating chemical reactions in living systems are vital for regulating circadian rhythms, metabolic processes, the transcription of DNA and other crucial biological functions1,2. Within the small-scale confines of a biological cell, molecular diffusion is sufficient to ensure that the reagents are ho...