Cellular target engagement technologies enable quantification of intracellular drug binding, but the simultaneous assessment of drug-associated phenotypes is challenging. Here, the authors develop CeTEAM (cellular target engagement by accumulation of mutant), a platform that can simultaneously evaluate drug-...
stages of drug development, yet it would be a good read for the drug discovery and drug development group as well. The traditional scope of textbooks and manuals on this topic is expanded here to include biological drugs, particularly therapeutic proteins and also botanical drugs or phytomedicines...
Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant. Int. J. Mol. Sci. 2021, 22, 1896. [Google Scholar] [CrossRef] [PubMed] Tamanoi, F.; Chinnathambi, S.; Laird, M.; Komatsu, A.; Birault, A.; Takata, T.; Doan, T....
Egis offers a wide range of intermediate and small molecule drug substance development and manufacturing services to its pharmaceutical partners. Its multifunctional production lines utilizes organic synthesis process for intermediates & drug substances....
We evaluated upadacitinib in patients with PsA and prior inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD).Methods In this 24-week randomised, placebo-controlled, double-blind, phase 3 trial, 642 patients were randomised (2:2:1:1) to once...
equal to 0.1ppm H2O2, hot sterile air is commonly used to dissipate hydrogen peroxide. Per US Food and Drug Administration, the concentration of H2O2must not be >500ppb at the time of filling and must be reduced to ~1ppb within 24h for the packaging material used to pack the food ...
However, in the drug discovery field, such advances remains scarce, and one of the reasons is intrinsic to the data used. In this review, we discuss aspects of, and differences in, data from different domains, namely the image, speech, chemical, and biological domains, the amounts of data...
& Zhu, J. Green and facile synthesis of highly biocompatible graphene nanosheets and its application for cellular imaging and drug delivery. J. Mater. Chem. 21, 12034–12040 (2011). 30 Banerjee, S. S., Jalota-Badhwar, A., Satavalekar, S., Bhansali, S., Aher, N., Mascarenhas, R....
sodium (Na) (so′de-um) A metallic element, atomic no. 11, atomic wt. 22.989768; an alkali metal oxidizing readily in air or water; its salts are found in natural biologic systems and are extensively used in medicine and industry. The s. ion is the most plentiful extracellular ion in ...
65,1928 TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 36 ppm/2H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TABIA2 Tabulae Biologicae....