an inverse correlation between click reactivity and payload release yield is hampering their clinical translation. Here, the authors develop ortho-substituted bis-pyridinyl-tetrazines with hydrogen-bonding hydroxyl or amido groups for efficient tautomerization and payload elimination, achieving release yields...
They do so by bonding with the enzyme acetylcholinesterase so that it can’t transmit chemical messages from the brain to the rest of the body. Once attached to the enzyme, nerve agents can’t be removed, explained Magliery. So the researchers are focusing on ways to stop the deadly ...
In the world of adhesives and bonding solutions, Adhesive Agent RS emerges as a game-changing component, reshaping the way we achieve strong and reliable bonds. Also known as "RS Adhesive," this innovative adhesive agent has become the cornerstone of various industries, offering precise and ...
By combining electron and photon detection methods from the solutions ionized or excited by soft X-rays we experimentally identify chemical bonding between the metal center and the CN ligand. Non-resonant photoelectron spectroscopy provides solute electron binding energies, and nitrogen 1 s and ...
Furthermore, the stoichiometry of anion-to-cation outdiffusion is altered by reactive interlayer, that is, “chemical trapping,” demonstrating the sensitivity of interface diffusion to local chemical bonding. Secondary phases may be present at the microscopic interface that are difficult to detect by...
While chemical shifts are generally sensitive mostly to the local (bonding) environment, there are cases where long-range and through-space effects are significant. For example, nuclear shielding may be significantly influenced by ring-current and electrostatic effects or paramagnetic centers. Solvent ef...
This is a 2-component elastomer as SEMICOSIL® 827 UV A and ELASTOSIL® CAT UV with 10:1 mixing ratio and a non-slump silicone adhesive that is cured by UV conditions with unique cure behavior for automotives.This is designed for oven-free processing or wet bonding during processing with...
Owing to the role of HS in controlling CO 2 in the ecosystem, advances in HS research could lead to new solutions for carbon capture and storage, thus contributing to address the urgent global challenge of increasingly rapid climate change [5]. Moreover, a better understanding of HS can be...
ArticleOpen Access11 Dec 2020Communications Chemistry Validating the CHARMM36m protein force field with LJ-PME reveals altered hydrogen bonding dynamics under elevated pressures Enzymes may behave differently at high pressures found in environments such as the ocean floor, but molecular dynamics force fiel...
Importantly, a class of high-enantioselectivity primary amine organocatalysts of 1,2-diphenylethane-1,2-diamine-based sulfonamides is discovered by the accelerated screening, and the mechanism for high-selectivity is demonstrated by computational chemistry. This study provides a practical and robust ...