colon cancergermline mutationshereditarysusceptibilityGermline mutations in cell cycle checkpoint kinase 2 (CHEK2) have been associated with a range of cancer types, in particular of the breast and prostate. Protein-truncating mutations in CHEK2 have been reported to confer higher risks of cancer of ...
[10] Ali M , Delozier C D , Chaudhary U .BRIP-1 germline mutation and its role in colon cancer: Presentation of two case reports and review of literature[J].BMC Medical Genetics, 2019, 20(1).DOI:10.1186/s12881-019-0812-0. [11] Uson PLS Jr, Riegert-Johnson D, Boardman L, Kisie...
in HCC with TP53 mutation. We then selected Nultin-3, which has been investigated as a potential therapeutic agent specifically targeting TP53-mutated cancer cells [16]. Furthermore, we further supplemented with 10 μM Nultin-3 in the previous knockout of CHEK2 HCC cell lines (LM3, Huh...
CHEK2 mutation and risk of prostate cancer: a systematic review and meta-analysis. Int J Clin Exp Med. 2015;8(9):15708-15715.PubMedGoogle Scholar 20. Cybulski C, Górski B, Huzarski T, et al. CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet. ...
Carriers who received RT for their first breast cancer, compared with non-carriers not treated with RT, had an RR of developing CBC of 2.6 (95% CI=0.8-8.7). We found no significant associations between the CHEK2*1100delC mutation and CBC overall or among those treated with RT. However,...
These mutations were associated with aggressive clinic-pathological characteristics; most of the subjects had IDC and triple-negative tumors, and a family history of cancer involving first-, second- and/or third-degree relatives (Table 2 and Figure 3). Only two mutation carriers did not have a ...
Other associations have been more variable, but CHEK2 mutations have been associated with increased risks of colon, prostate, and male breast cancer. Lung and laryngeal cancer are inversely associated in some studies, an intriguing and counterintuitive finding that awaits explanation.Robson M...
The I157T has been found to be associated with increased risk of breast, prostate, colon, kidney and thyroid cancer. The variability in penetrance and cancer expression in mutation carriers probably can be explained by influence of other genetic or environmental factors. Our preliminary data ...
After adjusting for mutation type, the risk of breast cancer was much higher among relatives of probands with breast cancer than among relatives of patients with prostate or colon cancer (HR=3.6; 95% CI=2.1-6.2; P=0.0001). Similarly, the risk of prostate cancer was higher among relatives ...
According to the study, 1.4% of the men with PCA exhibited the CHEK2 variant p.Ile157Thr, particularly those with family histories of breast or colon cancers. The results supported the hypothesis that the rate of CHEK2 variant p.Ile157Thr would be higher among men affected by PCA. This ...