Then ClusterProfiler results showed high CHEK2 and TP53 mutation group was positively enriched in the mitochondrial ATP pathway. Then we used MitoSox, electron microscopy, mitochondrial ATP, and NADH+/NADH assay and found knockout of CHECK could induce the ATP pathway to inhibit the growth of ...
Knockout of CHEK2 selectively induces proliferation arrest, cell cycle blockade, and senescence in HCC cells with TP53 mutation To elucidate the role of CHEK2 in HCC, we performed single-gene GSEA for CHEK2 using three databases: TCGA, ICGC, and GAO et al. We observed the enrichment of CHE...