Lubinski J, Narod SA. Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband. Br J Cancer. 2009 May 5;100(9):1508-12. doi: 10.1038/sj.bjc.6605038. PMID
Cancer RiskThyroid CancerSerum SeleniumBRCA1 CarrierCheckpoint kinase 2 (CHEK2) is as an important signal transducer of cellular responses to DNA damage and acts as a tumour suppressor gene. Mutations in the CHEK2 gene have been shown to be associated with increased risks to several cancers. In...
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【2】The authors wrote that women diagnosed with invasive lobular carcinoma of the breast rarely benefit from hereditary cancer testing because the involvement of PVs from cancer predisposition genes in invasive lobular ca...
The 1100delC CHEK2 allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North Americ
The proliferation of gene panel testing precipitates the need for a breast cancer (BC) risk model that incorporates the effects of mutations in several genes and family history (FH). We extended the BOADICEA model to incorporate the effects of truncating variants in PALB2, CHEK2, and ATM. Me...
It develops capsule-based system that utilizes low-dose X-rays to detect polyps, masses and colorectal cancer screening. The company was founded by Yoav Kimchy in 2005 and is headquartered in Isfiya, Israel.Show more --- CHEK Stock 12 Month Forecast All Analysts Top Analysts Average Price ...
Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband. Br J Cancer. 2009;100:1508-1512.Gronwald et al. (2009): Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in ...
Other associations have been more variable, but CHEK2 mutations have been associated with increased risks of colon, prostate, and male breast cancer. Lung and laryngeal cancer are inversely associated in some studies, an intriguing and counterintuitive finding that awaits explanation.Robson M...
CHEK2mutations are associated with increased cancer risks, including breast; however, published risk estimates are limited to those conferred byCHEK2founder mutations, presenting uncertainty in risk assessment for carriers of otherCHEK2mutations. This study aimed to assess phenotypes and molecular ...