Yes, if you have time to spare and want to do these steps, you certainly can, but you probably won't see a significant difference in your finished 4 patch quilt pattern. What does make a difference for this baby quilt? Make sure to pick precut charm packs made by the same manufacturer...
Baby Quilt Patterns Bed Quilt Patterns Most Patterns are Accuquilt Friendly which means you can use a QUBE set to cut them out and many include a chart for other QUBE sizes which equals to many different versions from ONE patterns!