Collectively, these findings highlight cell-specific mechanisms involved in the pathobiology of advanced COPD.doi:10.1038/s41467-022-28062-9Maor SaulerJohn E. McDonoughTaylor S. AdamsNeeharika KothapalliThomas BarnthalerJonas C. SchuppJessica Nouws...
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent inflammation and parenchymal lung tissue destruction, particularly in advanced disease stages1. COPD is commonly caused by aerosolized pollutants, such as cigarette smoke (CS); however, the clinical and biological effects of CS a...
Taken together, our data demonstrate the high degree of heterogeneity of ECs in fibrotic lung and it is proposed that the interaction between ECs, macrophages, and stromal cells contributes to pathologic IPF.Similar content being viewed by others Characterization of the COPD alveolar niche using ...
Characterization of adherence of nontypeable Haemophilus influenzae to human epithelial cells. The adherence of 58 nontypeable Haemophilus influenzae isolates obtained from patients with otitis media or chronic obstructive pulmonary disease (COPD) an... M Van Schilfgaarde,P Van Ulsen,P Eijk,... -...
Rationale: Asthma can coexist with chronic obstructive pulmonary disease (COPD), particularly in older adults, a condition labeled the overlap syndrome (OS). Additionally, while airway inflammation in COPD is generally neutrophilic, COPD patients may have features of asthma and thus a component of al...
Lung microbiome and cytokine profiles in different disease states of COPD: a cohort study Article Open access 07 April 2023 Association of bacterial community types, functional microbial processes and lung disease in cystic fibrosis airways Article 23 October 2021 Changes in sputum microbiota durin...
Particulate matter (PM) plays an important role in the earth’s atmosphere; however, it is poorly understood, particularly in urban areas. The present study focuses on the characterization of PM (i.e., PM10 > PM2.5 > PM1) in Lahore (Pakistan) during the winter months of the 201...
4B) was derived from the COPDGene study, one of the largest gene expression studies in individuals with chronic obstructive pulmonary disease (COPD). (GSE42057 dataset)22. Figure 3 Sex-based DNA methylation signals in X inactivated and Xi-escape genes. Visualization of Gene Methylation Signals ...
SUMMARY AT A GLANCE: NK and NKT-like cells are increased in the airways of subjects with COPD, with decreased expression of the inhibitory receptor CD94(Kp43) and increased NK cell cytotoxic potential. Investigation of treatment strategi... G Hodge,Mukaro,M Holmes,... - 《Respirology》 被引...
Characterization of Nonresponse to High Caloric Oral Nutritional Therapy in Depleted Patients with Chronic Obstructive Pulmonary Disease Nutritional support can increase body weight and physiologicfunction in COPD, but there are some patients who do not respond tonutritional therapy. The aim... EC Creutz...