Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis.We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected chil...
The results suggest the presence of multiple (possibly identical) copies of the genome in A. vinelandii . Only a fraction of the total number of genomes seem to have been tagged with transposon and an equilibrium between alleles of the same gene with and without the transposon was evident ...
ObjectiveThe 3.7?kb deletion (-α3.7) is the most common form of α+-thalassemia found in multiple populations which can be classified into three subtypes. In order not to mis-identify it, the molecular information within each population is required. We have addressed this in northeast Thai...
Two example of polygenic traits and height and skin color. Each are controlled by multiple genes, each with multiple alleles and produce a wide continuous expression of phenotype. What is a polygenic pattern? A polygenic pattern is a type of inheritance pattern where one trait is controlled by ...
Minimum-spanning tree of MRSA isolates based on MLST types in BJI, invasive infection and respiratory infection. Circle size indicates the number of each ST type. Differences in the length of the lines linking two circles indicate differences in the number (marked on the line) of alleles between...
The 'high' parent (with higher phenotypic mean) contributed to 64% of the alleles that increased the trait mean. QTL were unlinked, with no evidence for epistasis. Phenotypic variation for each QTL ranged from 8% to 37%. Multiple models accounted for from 28% (100-seed weight) to 69% ...
Sequence type (ST) 65 and ST86 differ by 5 out of the 7 alleles in the MLST (multilocus sequence typing) profile. The STs of the remaining pks-negative isolates are also distinct from ST65 and ST86. The new ST is a single locus variant of ST110. While originally identified as a ...
Calculation of the ratio of the two alleles after digestion was performed using a correction for the preferential amplification of one of the two alleles in the undigested sample. In silico DNA sequence analyses Genomic sequences determined on the basis of oligonucleotide coordinates from aCGH ...
Functional promoter activity of the human COX-2 gene in HMCs Volume 5, Issue 2, Pages (October 2013) Interaction between the G6PC2 rs G and rs G alleles on G6PC2 promoter activity. βTC-3 cells were transiently cotransfected, as described. ...
For each locus with two alleles identified, the allelic ratio was calcula- ted by dividing the peak height of the longer allele by the peak height of the shorter allele. Allelic ratios between 0.61 and 1.17 were consi- dered to be consistent with diploidy. Allelic ratios between 0.33 and ...