chaperone-mediated autophagy; CT: control; DMF: dimethyl fumarate; Emi: endosomal microautophagy; HG: high-glucose; HMOX1: heme oxygenase 1; H2O2: hydrogen peroxide; KFERQ: lysine-phenylalanine-glutamate-arginine-glutamine; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated ...
Wang G, Mao Z (2014) Chaperone-mediated autophagy: roles in neurodegeneration. Transl Neurodegener 3:20, doi:10.1186/2047-9158-3-20Wang G, Mao Z. Chaperone-mediated autophagy: roles in neurodegeneration. Transl Neurodegener. 2014;3:20. Central...
Using single-cell imaging of a fluorescent chaperone-mediated autophagy (CMA) reporter and RNA sequencing data, the authors present a resource on basal CMA activity across organs, cell types and sexes in young and old mice, offering a comprehensive overview of changes in this proteostatic mechanism...
Chaperone-mediated autophagy (CMA) is a type of autophagy that degrades proteins containing the KFERQ pentapeptide in cells. CMA can degrade damaged or excess proteins and therefore plays an important role in maintaining protein balance in cells. CMA can also play a regulatory role by degrading ...
In conclusion, OPTN knockdown was related to activation of ER stress response and chaperone-mediated autophagy, which tend to confine the damage caused by OPTN knockdown and thus question its value for PDAC therapy.doi:10.1038/s41420-019-0206-2Doaa M. Ali...
Chaperone-mediated autophagy(CMA) is an autophagy process in which substrate proteins in the cytoplasm are selectively bound by molecularchaperone proteins, transported to the lysosomal lumen, and then digested and degraded by lysosomalenzymes.90Recent studies have found that CMA is highly activated ...
are major sites of intracellular proteolysis. They are quite heterogeneous and participate in protein catabolism by several mechanisms. By chaperone-mediated autophagy, lysosomes selectively degrade proteins with KFERQ-like sequences (about 25–30% of all cell proteins) by a mechanism which resembles th...
Chaperone-Mediated Autophagy Chaperone-mediated autophagy(CMA) is a selective form of autophagy that targets cytosolic proteins carrying the KFERQpentapeptide, a sequence found in approximately 30% of cytosolic proteins (Chiang & Dice, 1988; Dice, 1990). This pentapeptide, which functions as adegron,...
chaperone mediated autophagylysosome-associated membrane protein type 2AmicrogliaSpinal cord injury (SCI)-induced ischemic delayed paralysis is one of the most serious side effects of aneurysms surgeries. Recent studies prove that the activation of autophagy, including macroautophagy and micro-autophagy ...
In this review, we focus on chaperone-mediated autophagy (CMA), a selective form of autophagy that modulates the turnover of a specific pool of soluble cytosolic proteins. Selectivity in CMA is conferred by the presence of a targeting motif in the cytosolic substrates that, upon recognition by...