The somatic mutations in a cancer cell genome may encompass several distinct classes of DNA sequence change. These include sub- stitutions of one base by another; insertions or deletions of small or large segments of DNA; rearrangements, in which DNA has been broken and then rejoined to a ...
Due to lattice restraints, the conformational changes that occur in the crystal, which drive the crystal phase transition, take place on a timescale much greater than that which occur in solution or under physiological conditions. Direct visualization by polarized video microscopy (PVM) reveals both...
The structural changes which occur in the heart, the lateral muscle and the large intestine during the development of cold water vibriosis in Atlantic salmon, Salmo salar L., have been studied by light and electron microscopy. The result... GK Totland,A Nylund,KO Holm - 《Journal of Fish...
The Lancet OncologySchulz WA. Do DNA-methylation changes also occur in blood? Lancet Oncol 2008; 9:312-3; PMID:18374285; http://dx.doi.org/10.1016/ S1470-2045(08)70083-4Schulz WA. Do DNA-methylation changes also occur in blood? Lancet Oncol. 2008;9:312-3....
The nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell differentiation. Germline stem cells (GSCs) express only LamB and predominantly emerin, whereas differentiating nur...
With a nitrogen mustard it was possible to show that the ultraviolet change did not occur immediately after alkylation but that it was a rapid post-treatment effect. The alkylated bases responsible for the changed absorption spectrum are labile and can be separated from the DNA by dialysis. No ...
Additional complications using IVW can occur in the presence of missing data, and when sample sizes are extremely small, as the actual number of possible permutations will be very low as well. Thus, LIMMA provides a more convenient and powerful framework to analyze such data than IVW. The ...
such as late autumn or winter in the Yangtze-Huaihe River Basin. Once wucai is exposed to a high-temperature environment, its growth will be inhibited and heat damage will occur [24]. Elucidating the regulatory pattern of the response of wucai to LT is thus of great interest. The wucai...
Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA barcodes to combine cell lineage readout with single-cell transcriptomics. However, reliance on transcriptional profiling limits adaptation to other single-cell assays. With CellTag-multi, we present an approach that ...
2CLCs emerge concomitant with DNA replication and display changes in replication timing (RT), particularly during the early S-phase. RT changes occur prior to 2CLC emergence, suggesting that RT may predispose to gene expression changes and consequent reprogramming of cell fate. Slowing down ...