1. 1. The genetic code was thought to be identical (“universal”) in all biological systems until 1981, when it was discovered that the coding system in mammalian mitochondria differed from the universal code in the use of codons AUA, UGA, AGA and AGG. 2. 2. Many other differences ...
making genetic prediction a difficult challenge. To better understand the plasticity of genetic interactions (epistasis), we combine mutations in a single protein performing a single function (a transcriptional repressor inhibiting a target gene). Even in this minimal system, genetic interactions switch...
These results indicate that cerebellar maturation is accompanied by significant reductions in the diversity of genetic information expressed in the tissue.Key Words: gene expression, RNA-DNA hybridization, polyadenylated RNA, cerebellum, postnatal development, ratSteven L. Bernstein...
The base changes leading to the production of revertants in particular classes were derived from amino-acid insertions, using the genetic code and knowledge that nonsense suppressors arise by single base alterations in the DNA information specifying certain tRNA anticodons. The mutagenic agents studied ...
The standard genetic code consists of 64 codons for a set of 20 amino acids and the stop signal, showing its redundancy (except for tryptophan and methionine) and implying that several synonymous triplets encode for the same amino acid. Usually, the position of such synonymous codons is not ...
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into totipotent-like 2-cell-like cell
more circular RNAs. Two lifespan-extending interventions, dietary restriction and lowered insulin–IGF signalling, both reversed most of these ageing-related changes. Genetic variants in RNA polymerase II that reduced its speed in worms5and flies6increased their lifespan. Similarly, reducing the speed...
the presumptive etiology of mood disorders in childhood and adolescence, for example, is also ‘complex’ and is thought to arise from ‘physical’ processes (inflammatory processes, chronic sleep disturbance, possibly the microbiome) and genetic factors [15,16,17] as well as from various types ...
These results thus suggest a profound effect of in vivo oxidative stress on the global hydroxymethylome. 展开 关键词: METHYLCYTOSINE OXIDATIVE stress SULFOXIMINES MICRORNA GENETIC code DOI: 10.1038/srep12714 被引量: 18 年份: 2015 收藏 引用 批量引用 报错 分享 ...
We map CS in more than 200 primary human and mouse cell types and increase CS annotations relative to the GENCODE database by 40%. Approximately half of all CS are used in few cell types, revealing that most genes only have one or two major 3′ ends. We incorporate the CS annotations...