aureus are reviewed in this article.doi:10.1586/14760584.7.6.805John R MiddletonExpert Rev VaccinesExpert Review of VaccinesMiddleton, J.R. (2008). Staphylococcus aureus, antigens and challenges in vaccine development. Exp Rev Vacc 6, 805-815....
The development of a new vaccine is a long-distance race between the virus and humans. Although tremendous progress has been made in reducing the viral transmission and fatality rate via vaccine administration, the emerging variants are challenging the protective efficacy of vaccines against symptomatic...
Although basic scientific immunological knowledge is the foundation for the development of novel vaccination approaches, beyond proof of concept in animal models, translational scientific immunological efforts are obligatory for successful development of a vaccine for use in humans. Translational technology is...
In recent years, extensive preclinical research and more than one hundred clinical trials have tested different strategies of neoantigen discovery and vaccine formulations. However, despite the enthusiasm for neoantigen vaccines, proof of unequivocal efficacy has remained beyond reach for the majority of ...
In this review, we summarize the current advances in the clinical trials associated with the development of COVID-19 vaccines and focus on the challenges and strategies of vaccine development against this unique and difficult species. 2. COVID-19 vaccines in development There has been an enormous...
The literature tends to focus more often on vaccine research problems associated with specific pathogens, but it is increasingly clear that there are common bottlenecks in vaccine research, which need to be solved in order to advance the development of the field as a whole. As part of a group...
The article explores the challenges in developing and testing HIV/AIDS vaccines in Africa. The historical perspectives on the disease was discussed. It examines the obstacles to HIV/AIDS vaccine development posed by human immunodeficiency virus. The potential risk for volunteers for HIV/AIDS vaccine ...
A vaccine against dengue is urgently needed, but vaccine development has been hampered by the lack of an appropriate animal model, poor understanding of correlates of successful human immunity, the fear of immune enhancement, and viral interference in tetravalent combinations. The most suitable target...
Murphy TF. Vaccine development for non-typeable Haemophilus in- fluenzae and Moraxella catarrhalis: progress and challenges. Expert Rev Vaccines 2005; 4:843-53.Murphy TF ( 2005 ) Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis : progress and challenges . Expert...
Fascination for vaccination: About achievements and challenges in the vaccine worldemerging infectionsequitable access to vaccinestraining of vaccinologistscommercial vs public health interestsThe mechanisms driving bone marrow stem cell mobilization are poorly understood. A recent murine study found that ...