KidneyFibrosisNephropathyBackground: Several studies revealed alterations of single sphingolipid species, such as chain length-specific ceramides, in plasma and serum of patients with kidney diseases. Here, we investigated whether such alterations occur in kidney tissue from patients and mice suffering ...
2). Palmitate increased media concentrations of diacylglycerides (DG), lysophosphatidylcholines (LPC) and ceramides (Fig. 2a; Supplementary Fig 3a). Specific species within these lipid classes - LPC 16:0, LPC 18:0, DG 32:0, ceramide 40:1 (N-(docosanoyl)-ceramide; Ceramide d18:1/22:0...
chain length (iso16:0,iso18:0, andiso20:0 as the least preferred BCFA) [8]. On the other hand, a study withiso15:0 BCFA performed on breast cancer cells SKBR-3 reported higher incorporation of BCFA into triacylglycerols [9]. BCFA may also be a constituent ofceramidespresent in...
We conclude that very long chain sphingolipids, when present in biological membranes, may affect the physical properties of or the distribution of sterols between lateral domains. It was also evident that not only the very long acyl chain but also the specific molecular structure of the ...
. This validates the use of GC-MS to quantify FAs with diverse chain length. Our results show strong enrichment of the hVLCFAs h22:0, h24:1, h24:0 and h26:0 in SYP61–CFP IP fraction as compared with Golgi/MEMB12–YFP IP fraction (Fig. 1j). Enrichment of sterols was also ...
Grosch S, Schiffmann S, Geisslinger G (2012) Chain length-specific properties of ceramides. Prog Lipid Res 51(1):50–62. https://doi.org/10.1016/j.plipres.2011.11.001 Article CAS PubMed Google Scholar Zigdon H, Kogot-Levin A, Park JW et al (2013) Ablation of ceramide synthase 2...
(PS)28,29,30. A small amount of SM is also distributed in the inner leaflet, where the lipid forms specific domains29. The effect of long chain ceramides (C16-ceramide and C18-ceramide) on the membrane organization of outer leaflet mimic (PC) and inner leaflet mimic (PE) artificial ...
Collectively, our results suggest that glucolipotoxicity induces β-cell apoptosis through a dual mechanism involving de novo ceramide biosynthesis and the formation of ceramides with specific N-acyl chain lengths rather than an overall increase in ceramide content.Biochemical Journal...
3A). Due to the exceptional length of the various VLC-FA made by ELOVL4, they are able to contribute unique biophysical properties to the cellular membranes that incorporate them, due to the number of methylene-interrupted cis double bonds within the acyl chain. The more saturated the chain ...
The properties of cosmetics vary depending on the cultures of countries. For example, in Japan, many cosmetics are based on fermented products because of the country’s long tradition of fermented foods. On the other hand, in South Asia, cosmetics based on medicinal herbs are considered common ...