CH223191 is a potent and specific antagonist of the aryl hydrocarbon receptor (AhR) that blocks activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; IC₅₀ = 0.03 µM; Kim et al.). It prevents the induction of cytochrome P450 1A1 by TCDD in HepG2 cells and in livers of ...
别名: CAS号:301326-22-7MDL号:分子式:C19H19N5O分子量:333.38706 MSDS大包装询价 货号规格产地品牌包装纯度货期价格促销价南通市数量操作 FY36792FEIYUBIO10MG>98%,AhR拮抗剂现货询¥884.00¥884.0010 -+ FY36793FEIYUBIO50MG>98%,AhR拮抗剂现货询¥2730.00¥2730.0010 ...
目的探究骨髓移植过程中辐射诱导的旁观者效应对供体骨髓细胞的影响以及芳香烃受体(AHR)抑制剂CH223191对供体骨髓细胞的保护作用.方法将小鼠分为9 Gy辐照组和12 Gy辐照组,不同辐照剂量辐射后移植相同数量供体骨髓细胞,流式细胞术检测外周血细胞总数,外周血供体细胞嵌合率及数量;ELISA检测未辐照小鼠和辐照小鼠血清活性氧...
CH-223191Description:.CH-223191ligand-selectiveantagonistAh(Dioxin)receptor.vitro:CH-223191preferentiallyinhibitssomeclassesAhRagonists(2,3,7,8-tetrachlorodibenzo-p-dioxinrelatedHAHs),others(PAHs,flavonoids,AhRsignaltransduction.CH-223191potentlyinhibitsTCDD-inducedAhR-dependenttranscription.addition,CH-223191blocked...
AhR-Mediated Effects of Dioxin on Neuronal Acetylcholinesterase Expression in Vitro The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, ... HQ Xie,HM Xu,HL Fu,... - 《Environmental Health Perspectives...
AHR抑制剂CH223191提高辐照后小鼠骨髓移植效果 骨髓中造血干细胞的数量与比例也明显高于对照组.结论:本研究证明CH223191在小鼠骨髓移植中,通过抑制AHR激活和降低细胞内ROS水平能够保护移植的供体细胞,减少辐射诱导... 庞瑞洋 - 《北京协和医学院》 被引量: 0发表: 2023年 ...
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本发明公开了一种AhR抑制剂CH223191在制备抑制肿瘤相关巨噬细胞药物中的应用,属于生物医药技术领域.本发明构建了偶联抗肿瘤相关M2型巨噬细胞表面高表达的CD206(甘露糖受体)的单克隆抗体,同时负载AhR抑制剂CH223191的纳米靶向递药系统(CD206NM@CH223191),特异性靶向黑素瘤肿瘤相关M2型巨噬细胞,以调控其AhR信号通路...
The model group was fed 0.2% adenine diet for 14 days to establish CKD model, while the treatment group was treated with AhR antagonist CH223191. AhR agonist kynurenine and antagonist CH223191 was applied in mouse tubular epithelial (TCMK-1) cells to investigate the underlying mechanisms of ...
subjected to L-kynurenine or L-tryptophan considering the production of anti-apoptotic proteins from the IAPs and Bcl-2 family, as well as the regulation of NF-κB signaling.The investigated substances were added alone or in combination with the AhR inhibitor (CH223191) to cultures of PANC-1...