Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin action via the glucose-responsive transcription factor ChREBP and its target, the fatty acid elongase ELOVL6. Gen...
3. E. Jeon et al. “Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK” Journal of Lipid Research, vol. 47, pp. 653-664, 2006 3421545129-59-9Methyl 13-methyltetradecanoate ...
The ChEMBL database recognizes various target types: pro:PR_0000001, verbchembl:ADMET, chembl:CELL-LINE, chembl:NUCLEIC-ACID, chembl:ORGANISM, chembl:SUBCELLULAR, chembl:TISSUE, chembl:UNCHECKED, and chembl:UNKNOWN. The latter two are currently defined as explicit types, thus effectively impl...
Using antibody isotype swapping, it may be possible to reduce systemic circulation through increased tissue localization, thereby minimising unwanted side effects. However, the effects of such modifications have yet to be fully characterized, particularly with regards to their biophysical properties in ...
A 3D human brain-like tissue model of herpes-induced Alzheimer's disease. Sci Adv. 2020;6(19):8828. https://doi.org/10.1126/sciadv.aay8828. Article CAS Google Scholar Belodurina AD, Muginova RF. The infectious and inflammatory nature of Alzheimer's Disease. Bulletin of the Council of...
TISSUE NUCLEIC-ACID PROTEIN FAMILY PROTEIN-PROTEIN INTERACTION PROTEIN COMPLEX GROUP SELECTIVITY GROUP CHIMERIC PROTEIN MACROMOLECULE SMALL MOLECULE OLIGOSACCHARIDE Remember earlier when I threw caution to the wind? How many of the assays are actually against human targets? I can join on the target id ...
免费在线预览全文 7 ytic Model Surgery Kim L. Erickson, William H. Bell and Douglas H. Goldsmith Surgical movements of the jaws are complicated surgeons strive to fulfill goals pertaining to both assessment, judgments will be made on the three-dimensional problems of geometrically of these compon...
It represents actual rectal tissue which has protruded through the anus. In young children it is associated with cystic fibrosis as well as other conditions. An external hemorrhoid or a prolapsed internal hemorrhoid is not moist and does not have the same mucosa. A perianal fistula represents a ...
altitudinis in the biocontrol of phytopathogenic fungal strains and as important bacteria associated with plant tissue. Our results contribute to our understanding of chili seed-surface-associated B. altitudinis CH05, which has relevant metabolic traits. It produces VOCs that affect the mycelial ...
A piece of ~3 cm in length was sampled at 5–6 cm from the basal part of each cutting. The rhytidome was removed, the cut surface was soaked with a drop of glycerol to avoid tissue flaking, and 50 µm cross-sections were obtained by using a rotary microtome (RM2245, Leica Micros...