cGAMP is a type 2 adjuvant that aids in inducing allergic asthma, specifically by agonizing the STING/TBK1/IRF3/7 axis. Thus, IL-33 and the IL-33 receptor (ST2) can be viewed as novel targets for the treatment of treat allergic asthma [83]. Anti-neutrophil cytoplasmic antibodies (ANCA)-...
7. Li XD, Wu J, Gao D, Wang H, Sun L, Chen ZJ. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (1979) [Internet].American Association for the Advancement of Science; 2013 [cited ...
The combination of CpG ODN and cGAMP inside pH-sensitive liposomes greatly improves the effectiveness of treatment for melanoma by enhancing the stability and cellular uptake of these adjuvants. The co-encapsulation results in a significant augmentation in the synthesis of type I and II interferons a...
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341, 1390–1394 (2013). Article ADS PubMed CAS Google Scholar Marsh, M. & Helenius, A. Virus entry: open sesame. Cell 124, 729–740 (2006). Article PubMed PubMed Central CAS Google Scholar...
5年后,STING的配体2'3'-环GMP-AMP(2'3'-cGAMP)和上游传感器cGAS(cyclic GMP-AMP synthase,GMP-AMP合成酶)被报道[5, 6],STING最公认的功能体现在cGAS-STING-IFN(Interferon,干扰素)信号通路中。然而新近研究通过结构生物学、生化...
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341, 1390–1394 (2013). Article CAS PubMed Google Scholar Gui, X. et al. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567, 262–266 (2019). ...
CpG ODNs, known for their capacity to enhance immunological responses, are commonly employed as adjuvants in vaccines and as immunotherapeutic agents in the treatment of cancer and infectious disorders. The combination of CpG ODN and cGAMP inside pH-sensitive liposomes greatly improves the ...
目前,STING活化可以概括为以下几个步骤:STING上游cGAS产生的cGAMP可以特异性激活STING的活化,诱导其发生显著的构象变化,并从内质网向高尔基体迁移,同时STING会发生寡聚化,招募TBK1,并活化IRF3[33, 34]。最新的结构生物学研究发现,在体外生化体系中重构STING寡聚化结构时,STING的合成激动剂C53可以结合到STING位于跨膜段...
但仍有一些核心步骤的分子机制还不清楚,例如:cGAMP如何诱导STING多聚化并将其激活、结合cGAMP后的STING如何招募并激活TBK1、激活后的TBK1如何磷酸化STING和IRF3等。 在今天online的两篇Nature文章中,德克萨斯大学西南医学中心陈志坚、张学武和白晓晨合作团队,运用结构生物学手段,并配合生化和细胞实验,阐明了这些信号转导...
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341: 1390-1394.Li XD, Wu J, Gao D, Wang H, Sun L, et al. (2013) Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341: 1390-1394. doi: 10.1126...