CF is the most common genetically inherited disease in Caucasian populations (1 in 3500 newborns in Europe) [13,14] and 70–90 % of CF individuals harbour the F508del mutation on at least one allele
The leading cause of cystic fibrosis (CF) is the deletion of phenylalanine 508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutation affects the thermodynamic stability of
2.2. Study Population Patients with cystic fibrosis were identified using the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis code E84.x. The study included patients diagnosed with cystic fibrosis between 1 January 2010 and 31 December 2022, who ...