华中科技大学硕士学位论文ER+/-乳腺癌细胞中MAPK信号通路激活与c-fos、c-jun及Survivin的关系研究姓名:万芳申请学位级别:硕士专业:妇产科学指导教师:钟刚;何福仙20040401
南昌大学医学院 硕士学位论文 卵巢癌c-Fos的表达及其与MAPK信号通路关系的研究 姓名:*** 申请学位级别:硕士 专业:病理学与病理生理学 指导教师:**红 20080601 摘要 摘要 目的:研究c.Fos蛋白在人卵巢癌细胞和组织中的表达及其与丝裂原活化蛋白激 酶(mitogen activated proteinkinases,MAPKs)信号通路关系的研究。
S. Kilberg, "MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells," Biochimica et Biophysica Acta, vol. 1853, no. 3, pp. 539-548, 2015.Shan J, Donelan W, Hayner JN, Zhang F, Dudenhausen EE,Kilberg MS. MAPK signaling triggers ...
AP-1在人肿瘤细胞中高度表达,且在肿瘤侵袭及转移中发挥重要作用;通过MAPK信号传导通路活化,调节胰腺癌细胞的侵袭和转移。AP-1调控的基因在侵袭转移过程中诱导MMPs表达,MMP-7与胰腺癌的侵袭转移机制密切相关。 【关键词】c-Fos,c-Jun,AP-1,MMP-7,肿瘤;侵袭;转移 c-Fos是一种具有潜在转活区域的重要的致癌因子...
Figure 1. 外部刺激诱发CREB-Fos 信号通路激活示意图[4]经颅磁刺激(rTMS)诱发神经元兴奋后,电压门控通道或兴奋性受体的配体门控通道打开,从而驱动细胞内Ca2+浓度的增加。蛋白激酶(ERK / MAPK途径)被激活,使磷酸化转录因子(ELK1和CREB)通过与Fos启动子结合驱动c-Fos 的表达。
MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: Regulation of enzymes involved in the degradation of fetal me... Fetal membranes overlying the cervix (i.e. supracervical site, SCS) are characterised by increased extracellular matrix (ECM) degradation...
图1:通过神经性刺激上调c-FOS表达水平。神经元兴奋后,电压门控通道或兴奋性受体的配体门控通道打开,从而驱动细胞内Ca2 +浓度的增加。接下来激酶(ERK / MAPK途径)被激活,使磷酸化转录因子(ELK1和CREB)通过与fos启动子结合驱动c-FOS表达上调。 一旦核内c-FOS水平升高,它就会与Fos家族的其他转录因子(例如c-JUN)...
本发明公开了山柰酚在骨关节炎治疗药物中的应用.山柰酚通过抑制炎症环境激活的NFκB与MAPK信号通路,下调感觉神经元中cFos,cJun与ΔFosB的表达,抑制转录因子激活蛋白1(AP1)与DNA结合的活性,从而降低感觉神经元中半乳糖凝集素1的表达,进而缓解骨关节炎的进展... 汤亭亭,梅竞天,乔涵,... 被引量: 0发表: 2019年 ...
S. Kilberg, "MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells," Biochimica et Biophysica Acta, vol. 1853, no. 3, pp. 539-548, 2015.Shan J, Donelan W, Hayner JN, et al. MAPK signaling triggers transcriptional induction of cFOS during ...
MAPK phosphorylation and activity were unaltered, but inducibility of cfos transcription was strongly impaired by insulin and reduced by PDGF. Induction of the cfos promoter via MAPK is mediated by activation of the ternary complex. Abundance of SRF or Elk-1 was unaltered, but Elk-1 ...