Pat. No. 7,718,657, which claims the benefit of U.S. provisional patent application No. 60/751,118, filed Dec. 16, 2005, all of which are incorporated herein by reference. The invention relates to certain substituted urea derivatives, particularly to certain chemical entities that selectively...
Molecular chaperones comprise a set of universally conserved proteins that bind and stabilize conformers of other proteins. A regulated, ATP-dependent association-dissociation cycle of the complex ensures the correct fate of the protein in vivo, which may be proper folding after synthesis, assembly in...