Background Cerebrospinal fluid (CSF) leakage is a common complication after neuroendoscopic surgery through a burr hole and can lead to further complications including infection. Methods We describe the use of a dural substitute larger than the burr hole itself, placed over the burr hole and then...
Effect of fibrin glue on the prevention of persistent cerebral spinal fluid leakage after incidental durotomy during lumbar spinal surgery Approximately one million spinal surgeries are performed in the United States each year. The risk of an incidental durotomy (ID) and resultant persistent c... ...
Syndrome of cerebral spinal fluid hypovolemia: clinical and imaging features and outcome. Neurology. 2000;55:1321–7. Kim SY, Hong JH. Epidural blood patches in a patient with multi-level cerebrospinal fluid leakage that was induced by... SM Hakim,SN Narouze - Springer New York 被引量: 0...
experimental data should be collected to directly show the penetration of the compounds into the CNS. Cerebral-spinal fluid (CSF) studies are usually conducted to calculate the CNS exposure of drug candidates204. An animal study showed that baicalin could cross the BBB and was detected in the CS...
It has been discovered that patients who are suffering from malaria have elevated amounts of kynurenine and it's metabolites in their cerebral spinal fluid. These metabolites include kynurenic acid, quinolinic acid, and picolinic acid [161], [162], [163]. There is a correlation between the ...
Mesial temporal lobe and long segment of spinal cord involvement may also occur. JE virus is a leading cause of viral encephalitis in Asia but is less common in the United States. Imaging findings are similar to WNV encephalitis, with bilateral T2 hyperintensities in thalami and brainstem. ...
Cerebral-spinal fluid (CSF) studies are usually conducted to calculate the CNS exposure of drug candidates[204]. An animal study showed that baicalin could cross the BBB and was detected in the CSF after single intravenous injection at a dosage of 24 mg/kg[207]. CGA was also detected in ...
In the study of spinal cord nerve injury, the inhibition of the HMGB1/NFκB axis can inhibit the pro-inflammatory polarization of microglia, which has a neuroprotective effect [106]. However, when AMPK/Nrf2 is activated synergistically, it can increase the polarization of macrophages in the M2 ...
Cerebral cavernous malformations (CCMs), also called “cavernous angioma” or “cavernoma,” are multilobed clusters of grossly dilated and thin-walled capillaries in the brain and spinal cord found in about 0.5% of the population. Patients with CCM lesions usually manifest with headache, epilepsy ...
Diameters of pial arteries were and acepromazine (3.3 mg/kg, intramuscular), and were main- measured using a cranial window method during applica- tion of artificial cerebrospinal fluid without drug, and cere- brospinal fluid containing LT C, D4, and L (1, ]0, 100, 1000, and 5000 ng/...