Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension. 2005;46(1):200–4. Article PubMed Google Scholar Jankowski J, Floege J, Fliser D, Bohm M, Marx N. Cardiovascular Disease in chronic kidney disease: pathophysiological...
Animal models of focal cerebral ischemia are well accepted for investigating the pathogenesis and potential treatment strategies for human stroke. Occlusion of the middle cerebral artery (MCA) with an endovascular filament is a widely used model to induce focal cerebral ischemia. However, this model i...
Mechanism of CBF decrease Although the mechanism of the long-term pericyte-mediated constriction of capillaries that occurs in human AD brains has not yet been definitively identified, short-term application of Aβ oligomers (both Aβ1–42and Aβ1–40, at nanomolar concentrations similar to those...
Cells were cultured in DMEM containing 10% v/v heat-inactivated fetal bovine serum (FBS), 2 mM glutamine, 10 U/mL penicillin, and 10 µg/mL streptomycin, at 37 ◦C and 5% CO2. Human brain microvascular endothelial cells (hBMEC) were purchased from ScienCell Research Laboratory (...