(2001) Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia. J. Alzheimers Dis. 3, 65-73.Ghiso J, Frangione B. Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia. J Alzheimers Dis 2001;3:65-73....
Cerebral amyloid angiopathy (CAA) is the common term used to define the deposition of amyloid in the walls of medium- and small-size leptomeningeal and cortical arteries, arterioles and, less frequently, capillaries and veins. CAA is an important cause of cerebral hemorrhages although it may also...
amyloid angiopathy (CAA) along with reduced cerebral blood flow that can further compromise cognitive capacity [129]. This phenomenon was also found in retina microvasculature [13,130]. In murine models of AD, it was recently found that vascular amyloid deposits hardened blood vessel walls and red...
Finally, our paper focusses on the more common and clinically relevant at a larger scale sporadic CAA, rather than the rare hereditary CAA syndromes (Greenberg et al., 2008) and hereditary systemic transthyretin amyloidosis with CAA (Sekijima et al., 2016) for which PET studies remain ...
Microvasculopathy is associated with the number of cerebrovascular lesions in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Stroke 1998;291588- 1594Google ScholarCrossref 40. Bornebroek MHaan JVan Duinen SG et al. Dutch hereditary cerebral amyloid angiopathy: structural lesions and ...
BCAS accelerated amyloid β (Aβ) convergence to the aggregation seed, facilitating the growth of Aβ plaques, but without changing the total Aβ amount in the brain. Furthermore, Aβ oligomers with high molecular weight increased in the brain of BCAS-operated mice. Considering Aβ is in an...
In addition to innate immune cells, the response of adaptive immune cells, especially T cells, to brain amyloidosis has also received increasing attention. In transgenic (tg) mouse models of AD-like cerebral amyloidosis, studies shown that brain amyloidosis promoted T cell infiltration but interfered...
Serum DHA levels (percentage of total fatty acids) were 23% lower in participants with cerebral amyloidosis than those without (0.97 vs 1.25, P = .007) and were inversely correlated with brain amyloid load (r = −0.32, P = .01) independent of age, sex, apolipoprotein E ...
The involvement of apolipoproteins, such as the ApoE4 isoform, in Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA) highlights the fact that certain lipid carriers may participate in soluble β-amyloid (Aβ) transport. Our general aim was to characterize the soluble levels of the...
Benedikz E, Merz GS, Schwenk V, Johansen TE, Wisniewski HM, Rushbrook JI: Cellular processing of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. Amyloid 1999;6:172–182. External Resources Pubmed/Medline (NLM) CrossRef (DOI) Chemical...