Symptoms of cerebellar degeneration include ataxia or wide-based gait, visual and speech dysfunction, dysmetria, and dyscoordination. The etiology of cerebellar degeneration is vast and often complex, and requires neuroimaging, lab assessments, and a thorough family history to delineate its cause. ...
Cerebellar ataxia is a condition in which a person experiences an inability to control certain voluntary muscle movements, like...
The same was observed for patient 2 (Additional file 10: Supplemental table I), a female with oculomotor abnormalities starting 3 years before the first symptoms of ataxia. If patients were not previously followed in our department, age of onset was determined based on patients’ motor and a...
blunt force injury, or vitamin deficiencies. Symptoms include stumbling, fine motor difficulties, dizziness, and impaired coordination of the torso or limbs Treatment involves addressing the cause of the damage and using appropriate treatment (antibiotics, anti-inflammatories, vitamin supplements, etc.)....
For many years, cerebellar ataxia has been thought to be incurable, and the treatment options are mainly limited 13 Molecular Neurobiology (2022) 59:3800–3828 3801 to managing the symptoms, rather than treating the direct cause of the diseases [12, 24, 25]. However, as a result of ...
Symptoms progress slowly in most patients. An association with late-onset type 1 diabetes and other auto-immune disorders is frequentlyReferences (13) G. Lauria et al. Excellent response to steroid treatment in anti-GAD cerebellar ataxia Lancet Neurol (2003) M. Solimena et al. Autoantibodies to...
Cerebellar ataxiaGlutamic acid decarboxylaseAutoantibodiesVertigoDiplopiaA prompt diagnosis and treatment of patients with autoimmune cerebellar ataxia (CA) with antibodies against glutamic acid decarboxylase (GAD-Abs) may lead to a better prognosis. Herein, we report prodromal transient neurological symptoms ...
Thirteen patients with childhood-onset ataxia and cerebellar atrophy had markedly decreased levels of CoQ10. Associated symptoms included seizures, developmental delay, mental retardation, and pyramidal signs. These findings confirm the existence of an ataxic presentation of CoQ10 deficiency, which may ...
The concept assumes that multiple lesions within or outside the basal ganglia and/or defective interactions among different nodes can explain the extrapyramidal symptoms [27]. Cerebellar Ataxias (CAs) In the systematic review by Nuzzo et al. [28], the therapeutic effects of non-invasive ...
Treatment with steroid and/or immunoglobulin was effective in improving symptoms, and the effect of these treatments continued for approximately 1 year. Conclusions: The present case suggested a potential diagnostic pitfall, in which the examination of serum anti-GAD antibody at initial evaluation alone...