Ceramides, which are membrane sphingolipids and key mediators of cell-stress responses, are generated by a family of (dihydro) ceramide synthases (Lass1-6/CerS1-6). Each ceramide synthase produces a specific subset of ceramides characterized by various acyl chains. Here, we report that brain ...
In this study, we demonstrate that the ceramide synthase 6 (CerS6) is primarily localized in podocytes of the glomeruli and is upregulated in two different models of diabetic mice. Podocyte-specific CerS6 knockout ameliorates glomerular injury and inflammatory responses in male diabetic mice and ...
In this study, we demonstrate that the ceramide synthase 6 (CerS6) is primarily localized in podocytes of the glomeruli and is upregulated in two different models of diabetic mice. Podocyte-specific CerS6 knockout ameliorates glomerular injury and inflammatory responses in male diabetic mice and ...
This was caused by a transiently increased expression of ceramide synthase (CerS) 6 in monocytes/macrophages and astroglia. Notably, this corresponds to the clinical finding that C16:0-Cer levels were increased 1.9-fold in cerebrospinal fluid of MS patients. NO and TNF-α secreted by IFN-γ–...
a,bRelative mRNA expression of the ceramide synthase (CerS) genes in hypothalamus samples of misty and db/db male mice (an = 5 vs. 7 mice), and C57BL/6 N male mice fed a control diet (CD) or high-fat diet (HFD) for 16 weeks (bn = 12 vs. 12 mice).cImmunoblot...
Here we report that the expression of Aldh1l1 in A549 or HCT116 cells results in the elevation of C16-ceramide and a transient up-regulation of ceramide synthase 6 (CerS6) mRNA and protein. Pretreatment with ceramide synthesis inhibitors myriocin and fumonisin B1 or siRNA silencing of CerS6 ...
0to be responsible for the increased susceptibility of COX-deficient cells to oxidative stress. Specifically, COX dysfunction enhances ceramide synthase 6 (CerS6) transcription and activity, which in turn results in C16 : 0ceramide accumulation, cytochrome c release and accelerated apoptosis ...
Results: Enzymatically inactive ceramide synthase 6 in mice (CerS6KO) results in an altered sphingolipid metabolism and behavioral abnormalities. Conclusion: Catalytically active CerS6 is necessary to maintain sphingolipid homeostasis in mice. Significance: The CerS6KO mouse reveals for the first time th...
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellula... S White-Gilbertson,T Mullen...
Ceramide synthase (sphingosine N-acyltransferase) is involved in the acylation of sphingosine and sphinganin (dihydrosphingosin) resulting in the formation of ceramide and dihydroceramide, respectively. From: Chemical Contaminants and Residues in Food (Second Edition), 2017 ...