In this study, we demonstrate that the ceramide synthase 6 (CerS6) is primarily localized in podocytes of the glomeruli and is upregulated in two different models of diabetic mice. Podocyte-specific CerS6 knockout ameliorates glomerular injury and inflammatory responses in male diabetic mice and ...
In this study, we demonstrate that the ceramide synthase 6 (CerS6) is primarily localized in podocytes of the glomeruli and is upregulated in two different models of diabetic mice. Podocyte-specific CerS6 knockout ameliorates glomerular injury and inflammatory responses in male diabetic mice and ...
Ceramide synthase 1|Ceramide synthase 1 基本信息更多信息 中文名称:Ceramide synthase 1 中文同义词:长寿相关基因LASS1抗体 英文名称:Ceramide synthase 1 英文同义词:Ceramide synthase 1;Rabbit Anti-Ceramide synthase 1 antibody CAS号: 分子式: 分子量:0 ...
the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our study was to investigate the relationship between ceramide synthase 1 and oral cancer. In this study, we found that the expression...
Summary Programmed death ligand 1 , PD-L1 (CD274), facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a mechanism whereby internalization of PD-L1 in response to alterations of bioactive lipid/ceramide metabolism by ceramide synthase 4 (CerS4) induces ...
serine palmitoyltransferase ORM-like protein ceramide synthase sphingolipids Originally sphingolipids were considered to be building blocks of all eukaryotic cell membranes. However, recent advances in our knowledge of sphingolipid metabolism, development of state of the art sphingolipidomic techniques, and ...
1e, f). Fig. 1: Hypothalamic CerS6 expression and C16:0 ceramide levels are increased in mouse models of obesity and diabetes. a, b Relative mRNA expression of the ceramide synthase (CerS) genes in hypothalamus samples of misty and db/db male mice (a n = 5 vs. 7 mice), and ...
1 silencing could be blocked by the pretreatment with SPT inhibitor myriocin, ceramide synthase inhibitor FB1, or PP2A inhibitor okadaic acid, suggested that the increased ceramide accumulation might be responsible for the development of insulin resistance induced by lipin-1 silencing in C2C12 myotubes...
Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18
(Fig. 30).388 These compounds showed low micromolar inhibitory activity against glycogen synthase kinase (GSK) 3β, which is an important point in the Wnt signaling pathway. Unusual sulfonylated ceramides –palyosulfonoceramides A (625) and B (626), which contain N-methyltaurine residue ...