and a surfactant that increases the solubility of the ceramide in the purified water, wherein the ceramide may be a mixed ceramide of two or more ceramides selected from the group comprising ceramide 1 (ceramide EOP), ceramide 2 (ceramide NS), ceramide 3 (ceramide NP), ceramide 5 (ceramide...
What determines drug solubility in lipid vehicles: Is it predictable? (vol 60, pg 638, 2008) Lipid-based drug delivery systems are of increasing interest to the pharmaceutical scientist because of their potential to solubilize drug molecules that m... SS Rane,BD Anderson - 《Advanced Drug Deliv...
Notably, analog 315 contains an imine functional group and a phenolic hydroxyl group, which increase permeability through the lipid bilayer as well as water solubility. More importantly, both compounds showed IC50 ranges in PEL cell lines that are much lower than those of other sphingolipid ...