Abstract 4294: C6 Ceramide potentiates paclitaxel and gemcitabine mediated antitumor effects against pancreatic cancer via inhibition of prosurvival PI3k/AKT/mTOR and ERK pathwaysdoi:10.1158/1538-7445.AM2019-4294The 5% survival of pancreatic cancer emphasizes need for new treatment strategies. Our studies...
New chemotherapy-enhancing strategies are needed for better cancer therapy. Previous studies suggest that exogenous cell-permeable C6 ceramide may be a useful adjunct to the anti-tumor effects of chemotherapeutic agents (such as Taxol) against multiple c
Furthermore, C1P stimulated the DNA binding activity of NF-κB, which is downstream of PKB or ERK, and blockade of this transcription factor also resulted in complete inhibition of macrophage migration. These observations suggested that MEK/ERK1-2, PI3-K/PKB (Akt) and NF-κB are crucial ...
Keywords: Trichostatin A; histone deacetylase inhibitors; C6-ceramide; PP1; AKT; Tubulin Abbreviations: PDMP, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol; CAPP, ceramide-activated protein phosphatase; HDACIs, Histone deacetylase inhibitors; MAP, microtubule-associated protein; PP1, Protein ...
3 reagents referenced in 2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells.
(b–d). HEK-293 cells stable transfected with Mock, SGK-1wt and SGK-1dn were stimulated with 50 μM C2-ceramide, C6-ceramide and C2-Dihy. After 48 h of treatment with ceramide, the cells were lysed and 100 μg of total proteins was separated on SDS-PAGE and immunoblotted ...
et al. C6-Ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth. Breast Cancer Res. Treat. 133, 447–458 (2011). PubMed Google Scholar Gouaze-Andersson, V. et al. Inhibition of acid ceramidase by a 2-substituted aminoethanol amide ...
Peyssonnaux, C. and Eychene, A. (2001) The Raf/MEK/ERK pathway: new concepts of activation.Biol. Cell93, 53–62. PubMedCASGoogle Scholar Yang, J., Yu, Y. N., and Duerksen-Hughes, P. J. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress....
We found that N-hexanoyl sphingosine (C6-ceramide) induced apoptosis efficiently through the accumulation of long chain ceramides. On the other hand, N-acetyl sphingosine (C2-ceramide) induced neither apoptosis nor accumulation of long chain ceramides. We also found that exogenously added C6-ceramide...
This ability of ceramide to activate PP2A was later found to mediate the ceramide effects on various substrates relevant to the induction of apoptosis, growth arrest or inflammation, including c-Jun, Bcl-2, Akt/PKB, Rb, PKC_, ERK1/2, IRAK-1, SR proteins and many others. Cathepsin D ...