近日,巴塞罗那基因组调控中心(Centre for Genomic Regulation)和英国剑桥韦尔科姆·桑格研究所(Wellcome Sanger Institute)的一个研究小组中的四名研究人员首次绘制出了一张完整的 KRAS 蛋白的薄弱部位图。 他们的突破性研究成果发表在本周一出版的世界顶级权威科学期刊《自然》(Nature)之上。研究确定了基因异位的控制位点...
Centre for Genomic Regulation – a hub for Integrative Biology in BarcelonaSeveral divergent standpoints are hosted under the umbrella of Peer Review. Authors, who wish to see the results of scrupulous work published, in the anticipation of career promotion or secure funding. Editors, who are ...
this recently launched HPC centre of excellence will optimise codes for cell-level simulations in HPC/Exascale and bridge the gap between organ and molecular simulations, thus contributing to the European Personalised Medicine Roadmap.
“This collaborative initiative will give the next generation of Danish scientists the opportunity to benefit from the Broad’s unique technology platforms as well as our expertise in genomic technologies, gene regulation, and data science.” The Novo Nordisk Foundation has committed to supporting t...
The positions in the table below reflect the French National Centre for Scientific Research (CNRS)'s position overall, domestically, within their sector, and in various subject areas based on their Share. Each position links to the corresponding table where French...
A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development 136, 139–146 (2009). Article CAS PubMed Google Scholar Navarro, P. et al. Molecular coupling of Xist regulation and pluripotency. Science 321, 1693–1695 (2008). This...
In eukaryotes transcriptional regulation often involves multiple long-range elements and is influenced by the genomic environment. A prime example of this concerns the mouse X-inactivation centre (Xic), which orchestrates the initiation of X-chromosome inactivation (XCI) by controlling the expression of...
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells The functions of androgen receptor (AR) in stromal cells are still debated in spite of the demonstrated importance of these cells in organ development and diseases. Here, we show that physiologica...
A genomic evaluation can assist some women diagnosed using autoimmune disease as well as their physicians to decide whether the cancer is very likely to return and when chemotherapy could provide advantages. Chemotherapy generally isn’t recommended for non-invasive, in situ cancers like DCIS only si...
PCR screening forrdl Genomic DNA was extracted from 290An. arabiensisSENN which underwent broflanilide bioassay testing and 219An. arabiensisSENN which were exposed to dieldrin. Individual mosquitoes were homogenized in a Qiagen TissueLyser II (Qiagen, UK) with sterilized 5 mm stainless steel beads...