Caroli disease (communicating cavernous biliary ectasia) is the congenital disease characterized by multifocal segmental saccular dilatation of intrahepatic bile ducts. On liver tomograms cystic formations (dilated bile ducts) may be detected with central enhancing dots or stripes (portal vein branches) –...
Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Ganstroenterology. 2009;136(7):2325–33. Article Google Scholar Takashima Y, Terada M, Kawabata M, Suzuki A. Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in...
BMC Cancer (2022) 22:1159 https://doi.org/10.1186/s12885-022-10269-0 RESEARCH Open Access Efficacy and safety of adjuvant chemotherapy in T1N0M0 intrahepatic cholangiocarcinoma after radical resection Xiao‑hui Li†, Chong‑yu Zhao†, En‑liang Zhou† and Xiao‑...
Sampaziotis et al. isolated cells from three regions of the biliary tree—intrahepatic bile ducts (IHD), common bile duct (CBD), and gallbladder (GB)—and performing single-cell RNA sequencing, Uniform Manifold Approximation and Projection (UMAP) analysis revealed that cells from these sources s...
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy. ICC comes from the bile ducts and its incidence is recently increasing [1, 2]. Currently, although several therapeutic strategies, such selective resection and intrahepatic arterial infusion of chemotherapy, are av...
[1]. The latter category may also include patients with an intrahepatic tumor that invades the hepatic duct confluence. Pathologic confirmation of PHC is not required prior to inclusion in the study. Patients are selected to potentially undergo a major liver resection if preoperative imaging with ...
(Radiometer America Inc.; Brea, CA). We measured bicarbonate levels in bile from healthy controls and patients with alcoholic cirrhosis since biliary bicarbonate secretion: (i) depends on and is closely associated with changes in intrahepatic biliary mass (DR) and activation of the Sct/SR ...
However, CD56 was also expressed in a subset of biliary epithelial cells, especially in intrahepatic small bile ducts, and thus it might not be the best marker of neuroendocrine tumors in the biliary duct [26]. In this study, more than half of the patients presented with perinerual invasion...
The largest group within this category had C71, C47, and malignant neoplasms of liver and intrahepatic bile ducts (C22). Additionally, two LFS-positive patients with multiple cancers were observed, both diagnosed with rhabdomyosarcoma and myeloid leukemia. Down syndrome, the third most notable CPS...
Hepatocytes and BECs: bile as a pivotal mediator Cholangiocytes, one of the main epithelial cells that constitute the liver parenchyma, are highly specialized cells that line the intrahepatic and extrahepatic bile ducts, participate in the production and homeostasis of bile [75]. Although the mecha...