Central Drug Research Institute and drug research[AB_STRACT]ML DharIndian Journal of Pharmacology
Fourth, ASOs can suppress the nonsense-mediated decay (NMD) of mRNA transcripts by targeting the exon-junction complex (EJC) region located downstream of a transcript’s premature termination codons (Fig.5A). Mechanistically, NMD is dependent on the presence of at least one EJC, and targeting t...
Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. To broadly explore artemisinin susceptibility in apicomplexan parasites, we employ genome-scale CRISPR scr
Adult male Sprague-Dawley rats aged 6–7 weeks weighing 200–220 g were purchased from the National Institute for Food and Drug Control in China. We only used male rats because the CPIP model was developed in male rats (Coderre et al., 2004); and microglial signaling in pain is sex-de...
This cross-sectional study was conducted in 2017–2018 on adults living in the Sang Siah neighborhood of Shiraz, located in south-central Iran. Known as the main slum neighborhood of Shiraz, Sang Siah is located in the old town texture of Shiraz and has a population of approximately two mill...
Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolde
47. slang a portion of a powdered drug for snorting 48. slang something said for effect, esp to solicit for money, sex, etc: he gave me his usual line. 49. (Accounting & Book-keeping) accounting denoting entries above a horizontal line on a profit and loss account, separating those ...
Steady-state protein abundance is set by four rates: transcription, translation, mRNA decay and protein decay. A given protein abundance can be obtained from infinitely many combinations of these rates. This raises the question of whether the natural rat
Since it is impos- sible to predict exactly how a fluorescent drug analogue will perform or distribute within a living cell careful phar- macological, chemical and biological validation of the fluo-ligand are required. Compounds that only show flu- orescence when they are bound to the receptor...
Siddha is a science of holistic health emphasizing both drug and diet for human health care. The Council has the vision of preservation and transmission of Knowledge and enhancement of the quality of research for developing drugs with quality, safety and efficacy through well-established preclinical ...