provided with a new direction and thrust from these developments. AI and ML has been applied to both ligand-based and structure-based drug discovery and design of CNS therapeutics. In this review, we have summarised the general aspects of AI and ML from the perspective of drug discovery follow...
Using in situ U–Pb geochronology, we have dated numerous volcanic rocks of the southern CEVP for the first time, giving precise age constrains for several localities previously dated mostly by the K–Ar method on whole-rock samples (Baranyi et al.1976; Horn et al.1972; Kraml et al.1995,...
Article Refining Species Traits in a Dynamic Vegetation Model to Project the Impacts of Climate Change on Tropical Trees in Central Africa Marie Dury 1,*, Lenni Mertens 1,2, Adeline Fayolle 3, Hans Verbeeck 4 , Alain Hambuckers 2 and Louis François 1 1 Modélisation du Climat et des ...
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Cyanobacteria from the genus Microcystis can form large mucilaginous colonies with attached heterotrophic bacteria—their microbiome. However, the nature of the relationship between Microcystis and its microbiome remains unclear. Is it a long-term, evolu
Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical for transmitting and amplifying intracellular signaling cascades initiated by an activated G
(2) eugregarines have replaced ubiquinol with another Q source, for which the synthesis pathway remains unknown (like RQ in the ciliateNyctotherus ovalis[64]); (3) eugregarines are utilizing COQ3 to methylate exogenously acquired 3-demethylubiquinol-n for the final step of UQ production; ...
μToMf)u, TrtrhLepr(d1e0lμinMea+t)e, atnhde Vmeehcihclaen(iPsBtiSc)ufonrd6erhp[i2n6n].ings of TrLp-mediated elimination of GL261 cells, we performed immunostaining and flow cytometry analysis of cultured GL22.36.1TcerLllps Ptroetaentetdly wUiptrhegCuLlapte(s1A...
The anthropogenic salinisation of rivers (especially the strong salinity that is associated with the discharge of salty mine waters, but also with the agents that are used to de-ice roads) and its impact on freshwater biota illustrates the consequences of climate change. The consequences of ...
on a daily basis, the cause often remains unknown and cannot be explained by hormonal and testicular disorders and genetic factors such as Klinefelter syndrome (XXY), rearrangements in the AZF gene, and mutations in other infertility related genes, such as AR, CFTR, NR5A1,...