Direct cellular production of topologically complex proteins is of great interest both in supramolecular chemistry and protein engineering. We describe the first cellular synthesis of protein catenanes through
Direct cellular production of topologically complex proteins is of great interest both in supramolecular chemistry and protein engineering. We describe the first cellular synthesis of protein catenanes through the use of the p53 dimerization domain to guide the intertwining of two protein chains and ...
Zhang Cellular synthesis of protein catenanes Angew. Chem. Int. Ed., 55 (2016), pp. 3442-3446 CrossrefView in ScopusGoogle Scholar 22 D. Liu, W.H. Wu, Y.J. Liu, X.L. Wu, Y. Cao, B. Song, X.P. Li, W.B. Zhang Topology engineering of proteins in vivo using genetically ...
Direct cellular production of topologically complex proteins is of great interest both in supramolecular chemistry and protein engineering. We describe the first cellular synthesis of protein catenanes through the use of the p53 dimerization domain to guide the intertwining of two protein chains and ...
Direct cellular production of topologically complex proteins is of great interest both in supramolecular chemistry and protein engineering. We describe the first cellular synthesis of protein catenanes through the use of the p53 dimerization domain to guide the intertwining of two protein chains and ...
protein designprotein engineeringprotein structuresProtein heterocatenanes could be readily and modularly synthesized in cellulo using a programmed sequence of post‐translational processing events, including intramolecular chain entanglement, in situ backbone cleavage, and spontaneous cyclization. The catenane ...
coli Topo III can act as the principal cellular decatenase, capable of unlinking replicating daughter chromosomes in vivo, and provide evidence that this decatenation proceeds via the removal of precatenanes. EXPERIMENTAL PROCEDURES Enzymes, Reagents, Proteins, and Antibodies Restriction enzymes and ...
protein structuresHerein, we report the biosynthesis of protein heterocatenanes using a programmed sequence of multiple post-translational processing events including intramolecular chain entanglement, insitu backbone cleavage, and spontaneous cyclization. The approach is general, autonomous, and can obviate ...
coli Topo III can act as the principal cellular decatenase, capable of unlinking replicating daughter chromosomes in vivo, and provide evidence that this decatenation proceeds via the removal of precatenanes. EXPERIMENTAL PROCEDURES Enzymes, Reagents, Proteins, and Antibodies Restriction enzymes and ...
ProteinTopologyHerein, we report the biosynthesis of protein heterocatenanes via a programmed sequence of multiple post‐translational processing events including intramolecular chain entanglement, in situ backbone cleavage, and spontaneous cyclization. The approach is general, autonomous, and can obviate the...