Chronic kidney disease (CKD) is increasingly being accepted as a type of renal ageing. The kidney undergoes age-related alterations in both structure and function. To date, a comprehensive analysis of cellular senescence and senescence-associated secretory phenotype (SASP) in CKD is lacking. Hence,...
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting thes
Chronic kidney disease (CKD) is an increasing major public health problem worldwide. And CKD shares numerous phenotypic similarities with kidney as well as systemic ageing. Cellular senescence is mainly characterized by a stable cell cycle arrest, senescence-associated secretory phenotype (SASP) and se...
skip to main content advertisement a multidimensional systems biology analysis of cellular senescence in aging and disease abstract background cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related ...
The excessive accumulation of senescent cells in various tissues correlates well with age-related metabolic disorders and the development of premature chronic disease [35]. Of note, concomitant with cellular senescence, another common feature of ageing-related conditions is persistent low-grade sterile ...
Baicalin is a natural flavonoid glycoside which has potent anti-tumor and antioxidant activity in cancer cells. In the present study, we found that baicalin treatment significantly induced senescence in colon cancer cells. Furthermore, baicalin upregulat
Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis Physiologic and Pathologic Images of the Retina. (a) Structure diagram of retinal layers and immunosuppressive mechanism in the retina; (b) Pathological changes in dry AMD: drusen formation, RPE ...
Knockdown of miR-200c expression with miR-200c-3p-shRNA significantly reduced senescence phenotype and enhanced cell proliferation in NHKs after irradiation. The generation of reactive oxygen species (ROS) and p47 enzyme involved in ROS production was increased after irradiation but both w...
Therapy-induced cellular senescence describes the phenomenon of cell cycle arrest that can be invoked in cancer cells in response to chemotherapy. Sustained proliferative arrest is often overcome as a contingent of senescent tumor cells can bypass this c
promoted cellular senescence, possibly through upregulation of tumor-suppressor genes, such asp53andp21. Most importantly, WIF1 significantly diminished the number of salivary gland cancer stem cells and the anchorage-independent cell growth. Consistent with this observation, WIF1 caused a reduction in...