Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging
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Outline Highlights Abstract Keywords 1. Ageing of the skin 2. Cellular senescence 3. Evidence for a role of cell senescence in intrinsic skin ageing 4. Conclusions and open questions Funding ReferencesShow full outline Cited by (62) Figures (3) Tables (3) Table 1 Table 2 Table 3...
Gorgoulis, V. et al. Cellular senescence: defining a path forward.Cell179, 813–827 (2019). ArticleCASPubMedGoogle Scholar Sharpless, N. E. & Sherr, C. J. Forging a signature of in vivo senescence.Nat. Rev. Cancer15, 397–408 (2015). ...
Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological functions beyond being a putative tumor suppressive trait. It remains unknown whether low levels of oxygen or hypoxia, which is a feature of every ...
Considering the molecular functions of EZH2 and TOP2A, they may play a regulatory role in cellular senescence. However, the mechanism underlying the regulatory role of EZH2 and TOP2A in cellular senescence, particularly in the context of HCC, has not been established. In this study, we found ...
Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as a hallmark of cancer. It exerts a context-dependent dual role in cancer initiation and progression, functioning as a tumor suppresso
2i). Through comparing enrichment levels of OCLR-learned features among 268 cell types from the CellMarker database104 and a widely used senescence-associated gene set (SenUP)105 by GSEA, we observed a more significant positive enrichment for SenUP compared to cell type marker sets, indicating...
Cellular senescence has gained increasing interest during recent years, particularly due to causal involvement in the aging process corroborated by multiple experimental findings. Indeed, cellular senescence considered to be one of the hallmarks of aging, is defined as a stable growth arrest predominantly...