et al. Cellular senescence: defining a path forward. Cell 179, 813–827 (2019). Article CAS PubMed Google Scholar Sharpless, N. E. & Sherr, C. J. Forging a signature of in vivo senescence. Nat. Rev. Cancer 15, 397–408 (2015). Article CAS PubMed Google Scholar Fuhrmann-Stroi...
One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due to the many proteins they secrete. In preclinical models,...
Cellular Senescence: Defining a Path Forward Vassilis G. Gorgoulis, Peter Adams, Andrea Alimonti … (2019) Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve...
Considering the molecular functions of EZH2 and TOP2A, they may play a regulatory role in cellular senescence. However, the mechanism underlying the regulatory role of EZH2 and TOP2A in cellular senescence, particularly in the context of HCC, has not been established. In this study, we found ...
Senescence is also characterized by a senescence-associated (SA) secretory phenotype (SASP) in which cells produce and secrete inflammatory cytokines, such as interleukin (IL)-6 and IL-8, chemokines, matrix metalloproteinases (MMPs), growth factors, and angiogenic factors (Kim and Park, 2019; ...
Cellular senescence has been regarded as a therapeutic target for ageing and age-related diseases. Several senotherapeutic agents have been proposed, including compounds derived from natural products which hold the translational potential to promote healthy ageing. This systematic review examined the associa...
[96,99,100]. However, inducing cancer cell senescence is a double-edged sword, which can either lead to the reduction of PCa cell growth or enhance the “activity” of PCa cells or cause them to relapse. Therefore, understanding TIS’s exact mechanism and role in PCa will help prevent ...
Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological fu
et al. Cellular senescence: defining a path forward. Cell 179, 813–827 (2019). Article CAS PubMed Google Scholar Welle, S. et al. Skeletal muscle gene expression profiles in 20–29-year-old and 65–71-year-old women. Exp. Gerontol. 39, 369–377 (2004). Article CAS PubMed Google...
Here, to overcome the limitation of measuring individual markers, we describe a detailed two-phase algorithmic assessment to quantify various senescence-associated parameters in the same specimen. In the first phase, we combine the measurement of lysosomal and proliferative features with the expression ...