(e.g., nucleic acid metabolic, RNA metabolic, nucleobase-containing compound metabolic, heterocycle metabolic, cellular aromatic compound metabolic, organic cyclic compound metabolic processes), cell division and cell cycle (e.g., negative regulation of mitotic cell cycle and cell cycle phase ...
Breast cancer susceptibility gene 1 (BRCA1) plays a significant role in the genomic stability of cells in response to oxidative DNA damage [51]. Under oxidative stress, the genomic integrity of the cell is compromised. BRCA1 is reported to regulate cellular oxidative stress by activating the exp...
Cyclic AMP is a messenger that causes different responses depending on the cell type (Table 25.1). Although tissue response varies according to the tissue considered, in all cases the action of cAMP is carried out through “cascade” reactions initiated with activation of protein kinase A, and ...
Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and cancer stem cells and is frequently used to is
The combined organic layers were washed with H2O (2×150 mL), brine (150 mL), dried over Na2SO4 and evaporated under reduced pressure to obtain the desired compound 5 (4.62 g, 8.46 mmol, 97%) as a white solid, which was used for the next step without further purification. 1H NMR ...
“physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid ...
The present invention relates to (1- or 2- and/or 5 and/or 7-substituted)-(3-oxy)-(4H, 4-imino, 4-thioxo or 4-oxo)-pyrazolo[3,4-d]pyrimidin-6-ones, e.g., a compound of formula II as
4.The compound according to claim 1, wherein the compound is a compound of Formula I(i):wherein(i) R1is C1-4alkyl;(ii) R4is H and R2and R3are independently C1-6alkyl;(iii) R5is attached to one of the nitrogens on the pyrazolo portion of Formula I(i) and is a moiety of Form...
2. The compound according to claim 1, wherein said compound is a Compound of Formula II wherein (i) L is S, SO or SO2; (ii) R1 is H or C1-4 alkyl; (iii) R4 is H or C1-6 alkyl and R2 and R3 are, independently, H or C1-6alkyl optionally substituted with halo or hydroxy...
6. A composition comprising said salt of a compound of claim 1, wherein said salt is an acid salt; said acid is selected from the group consisting of inorganic and organic acids. 7. A composition comprising a compound of claim 1 for pharmaceutical, nutraceutical, cosmetic, topical, or oral...