The study aimed to evaluate in different groups of workers, chronic exposure, through peripheral biomarkers, the potential effects of chemical agents on phenotypic and genotypic expressions of tumor-related proteins in mononuclear cells. This study evaluates 85 taxi drivers (outdoor workers) and 55 ...
While the initial response to stress is geared towards activation of pro-survival CSRPs, the shift towards a PCD-associated stress response is activated when stress resolution is not possible. Ultimately, the balance between pro-survival and PCD-associated CSRPs determines whether cells survive or...
all eukaryotes react rapidly to ER dysfunction through a set of adaptive pathways known collectively as the ER stress response (ESR). Normally, this suite of responses succeeds in restoring ER homeostasis. However, in metazoans, persistent or intense ER stress can...
less clear are the downstream molecular events utilized by cells to respond to harsh mechanical stimuli and abrogate long-term deleterious effects12. To date, perhaps the best understood molecular response to mechanical stressors has been described in the heart. Cardiomyocytes experience increased...
et al. The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ. 20, 1485–1497 (2013). Article CAS PubMed PubMed Central Google Scholar Passos, J. F., Simillion, C., Hallinan, J., Wipat, A. & von Zgli...
For both strains, the cellular viability loss and lipid peroxidation was lower for the cells exposed to increased air pressure than for those exposed to chemical oxidants. The glutathione induction occurred only in Y. lipolytica strain and reached the highest level as a response to PQ exposure. ...
stress. It’s a nootropic and an adaptogen, as it helps us to adapt and resist certain stressors. The herb grows in Asia and Eastern Europe and has been used in traditional medicine for many centuries. It contains over 40 chemical compounds with the two most notable being rosavin and ...
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress ...
We identified significant upregulation of Nedd8 and Lgmn proteins in similar levels which may contribute to UPR stress. Interestingly, the downregulation of Hspa5/Bip and Pdia4 in response to tunicamycin treatment suggests a low-level UPR activation. Key points • Proteome profiling of recombinant ...
Senescence is a cell’s fate elicited in response to external and internal cellular stress signals, established through transcription factor cascades that can include p16INK4a (p16)/retinoblastoma protein and/or p53/p21CIP1 (these factors are thought as the markers of cellular senescence). ...