Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells We investigated the induction of a stress response gene by anticancer drugs that damage and covalently modify DNA and other cellular macromolecules. Two human colon adeno-carcinoma cell lines ...
which is activated by DNA damage; the oxidative stress response system, which is activated by excess reactive oxygen species (ROS) and imbalances in the oxidant/antioxidant status within cells; and the heat shock response, which is activated by exposure to heat and other agents that adversely aff...
The immune system uses this combination of actions to exert a small local inflammatory action and to resolve the initial problem. In situations of stress and chronic inflammation, this mechanism may accentuate local inflammation and create a favorable microenvironment for cancer cells (Impellizzeri and...
Mechanisms are described that involve altered uptake and efflux of chemical agents, intracellular detoxification, and DNA damage responses. Many of these changes trigger a cascade of reactions mediated by stress-activated signaling pathways, which have the capacity to determine whether a cell will ...
Although the mammalian embryo develops within the protective environment of the uterus, this protection is not absolute and we now know that mammalian development can be perturbed by a wide variety of chemical and physical agents, many of which are known to induce one or more of these stress ...
Chemical-induced oxidative stress to a cell can signal many cellular responses which include proliferation, differentiation, hemeostasis, apoptosis or necr... A Kong - 《Restor Neurol Neurosci》 被引量: 83发表: 1998年 Activation of the c-Jun N-Terminal Kinase Pathway by a Novel Protein Kinase...
The 'Cellular Stress Response' refers to the activation of heat-shock proteins (HSP) in cells when they are exposed to various physical or chemical treatments, such as a transient rise in temperature or low oxygen levels. These heat-shock proteins help repair the damage caused by these conditio...
Additional experiment assessing kinetics of excystment indicated that it can occur less than 9 h following mechanical stress (centrifugation) and that 75% of the culture can excyst within 24 h. Upon 30 min of exposure to chemical stressors (saponine and H2O2), only ...
Cellular stress responses are critical mechanisms that allow cells to adapt to and cope with various environmental stressors. These stressors can be physical, chemical, or biological in nature and can cause damage to cellular components such as DNA, proteins, and membranes. In response to stress,...
For both strains, the cellular viability loss and lipid peroxidation was lower for the cells exposed to increased air pressure than for those exposed to chemical oxidants. The glutathione induction occurred only in Y. lipolytica strain and reached the highest level as a response to PQ exposure. ...