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Suture repairs allow for the reattachment of the tissues but significant fibrosis compromises their mechanical properties and leads to structural and mechanical failure with rates between 20 and 94% at the surgical site [109], [112]. Alternative treatments are needed to address the poor regeneration...
The DNA damage response (DDR) is a complex and highly regulated cellular process that detects and repairs DNA damage. The integrity of the DNA molecule is crucial for the proper functioning and survival of cells, as DNA damage can lead to mutations, genomic instability, and various diseases, ...
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death Science, 352 (2016), pp. 359-362 CrossrefView in ScopusGoogle Scholar Radulovic et al., 2018 M. Radulovic, K.O. Schink, E.M. Wenzel, V. Nähse, A. Bongiovanni, F. Lafont, H. Sten...
Regarding mitochondrial function, our own studies showed that C15:0 repairs mitochondrial function, including a significant reduction in mitochondrial reactive oxygen species; effective C15:0 concentrations were between 10 and 50 µM, with optimal efficacy at 20 µM (5 µg/mL) [47]. This ...